An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

Analyte Monitoring Device And Methods Of Use

A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery. Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.

Rechargeable spinal cord stimulator system

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more intracranial (IC) stimulating electrodes in accordance with treatment parameters. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease

▪ Abstract Paralyzed or paretic muscles can be made to contract by applying electrical currents to the intact peripheral motor nerves innervating them. When electrically elicited muscle contractions are coordinated in a manner that provides function, the technique is termed functional electrical stimulation (FES). In more than 40 years of FES research, principles for safe stimulation of neuromuscular tissue have been established, and methods for modulating the strength of electrically induced muscle contractions have been discovered. FES systems have been developed for restoring function in the upper extremity, lower extremity, bladder and bowel, and respiratory system. Some of these neuroprostheses have become commercialized products, and others are available in clinical research settings. Technological developments are expected to produce new systems that have no external components, are expandable to multiple applications, are upgradable to new advances, and are controlled by a combination of signals, ...

https://www.annualreviews.org/doi/pdf/10.1146/annurev.bioeng.6.040803.140103

Functional electrical stimulation for neuromuscular applications

This paper describes the development of a high-density electronic interface to the central nervous system. Silicon micromachined electrode arrays now permit the long-term monitoring of neural activity in vivo as well as the insertion of electronic signals into neural networks at the cellular level. Efforts to understand and engineer the biology of the implant/tissue interface are also underway. These electrode arrays are facilitating significant advances in our understanding of the nervous system, and merged with on-chip circuitry, signal processing, microfluidics, and wireless interfaces, they are forming the basis for a family of neural prostheses for the possible treatment of disorders such as blindness, deafness, paralysis, severe epilepsy, and Parkinson's disease.

/pdf/wireless-implantable-microsystems-high-density-electronic-2s60s28lz9.pdf

Wireless implantable microsystems: high-density electronic interfaces to the nervous system

An input command controller (A) provides logic function selection signals and proportional signals. The signals are generated by movement of a ball member (12) and socket member (14) relative to two orthogonal axes. When the joystick is implanted, a transmitter (50) transmits the signals to a patient carried unit (B). The patient carried unit includes an amplitude modulation algorithm such as a look-up table (124), a pulse width modulation algorithm (132), and an interpulse interval modulation algorithm (128). The algorithms derive corresponding stimulus pulse train parameters from the proportional signal which parameters are transmitted to an implanted unit (D). The implanted unit has a power supply (302) that is powered by the carrier frequency of the transmitted signal and stimulation pulse train parameter decoders (314, 316, 318). An output unit (320) assembles pulse trains with the decoded parameters for application to implanted electrodes (E). A laboratory system (C) is periodically connected with the patient carried unit to measure for changes in patient performance and response and reprogram the algorithm accordingly. The laboratory system also performs initial examination, set up, and other functions.

Functional neuromuscular stimulation system

Through the use of semicustom integrated circuit technology, an implantable muscle stimulator has been developed. The unit is small, lightweight, has low power consumption, and is intended for permanent usage. The stimulator circuitry is externally controlled and powered by a single encoded radio frequency carrier. Up to eight independently controlled stimulus output channels are provided, with output channel selection, stimulus pulse width, and stimulus pulse frequency under external control. A constant current biphasic stimulus pulse is used, in which the stimulus current amplitude can be preset by a single resistor value. The stimulator circuitry has been implemented in thick film hybrid form, and has undergone laboratory evaluation for 48 months.

An Externally Powered, Multichannel, Implantable Stimulator for Versatile Control of Paralyzed Muscle

Using the reflected impedance property of an inductive couple (transformer), a modulation method, load-shift keying using circuit configuration modulator (LSK-CCM), was developed to perform data transmission from an implantable telemeter. With a very simple circuit, this method utilizes a radio-frequency electromagnetic field induced with a single pair of coils to transmit power into the implant and data out of it. >

Data transmission from an implantable biotelemeter by load-shift keying using circuit configuration modulator

A neural prosthesis includes a centralized device that can provide power, data, and clock signals to one or more individual neural prosthesis subsystems. Each subsystem may include a number of individually addressable, programmable modules that can be dynamically allocated or shared among neural prosthetic networks to achieve complex, coordinated functions or to operate in autonomous groups.

Implantable networked neural system

An input command controller provides logic function selection signals and proportional signals. The signals are generated by movement of a ball member and socket member relative to two orthogonal axes. When the joystick is implanted a transmitter transmits the signals to a patient carried unit. The patient carried unit includes an amplitude modulation algorithm such as a look-up table, a pulse width modulation algorithm, and an interpulse interval modulation algorithm. The algorithms derive corresponding stimulus pulse train parameters from the proportional signal which parameters are transmitted to an implanted unit. The implanted unit has a power supply that is powered by the carrier frequency of the transmitted signal and stimulation pulse train parameter decoders. An output unit assembles pulse trains with the decoded parameters for application to implanted electrodes. A laboratory system is periodically connected with the patient carried unit to measure for changes in patient performance and response and reprogram the algorithm accordingly. The laboratory system also performs initial examination, set up, and other functions. A percutaneous interface structure is provided which facilitates cleansing the area of the limb around the electrode leads, which protects the lead wires from damage and catching and which protects the patient against catching the lead wires and pulling or ripping the electrodes form the implantation site.

Brian Smith

Papers

Functional neuromuscular stimulation system

An Externally Powered, Multichannel, Implantable Stimulator for Versatile Control of Paralyzed Muscle

Data transmission from an implantable biotelemeter by load-shift keying using circuit configuration modulator

Implantable networked neural system

Functional neuromuscular stimulation system with shielded percutaneous interface