Bridget K. Buckmeier Butz

TL;DR: An esophageal mast cell- associated transcriptome that is significantly divergent from the eosinophil-associated transcriptome is identified, with carboxypeptidase A3 mRNA levels serving as the best mast cell surrogate marker; and evidence for the involvement of KIT ligand in the pathogenesis of EE is provided.

TL;DR: Evidence is presented that IL13 and IL5 associate with eosinophil and eotaxin-3 levels, indicating the key role of adaptive T(H)2 immunity in regulating eotAXin- 3-driven esophageal eos in the absence of a consistent systemic change in cytokines.

TL;DR: Daily administration of a high dose of FP induces histologic remission in 65%-77% of patients with EoE after 3 months, and nonresponders had evidence of steroid resistance; histologic and molecular markers may predict resistance.

TL;DR: In this paper, a nested case-control study of patients with retrospectively identified histologic eosinophilic esophagitis (rEoE) and chronic EoE, as well as an age-matched control cohort was conducted.

TL;DR: Esophageal eosinophilia at levels consistent with EE was present among 30% of patients given diagnoses of reflux esophagitis, and the incidence of esophageAL eos inophilia did not change over time.