Showing papers by "Brigitte Chamak published in 1991"
TL;DR: The results suggest that brain macrophages could favour the appearance of neuroregressive events which occur either during neurogenesis or in neurodegenerative diseases, implying intracerebral recruitment of mononuclear phagocytes.
Abstract: Brain macrophages are transiently present in different regions of the central nervous system during development or in the course of tissue remodelling following various types of injuries. To investigate the influence of these phagocytes on neuronal growth and survival, brain macrophages stemming from the cerebral cortex of rat embryos were added to neuronal primary cultures. A neurotoxic effect of brain macrophages was demonstrated by the reduction of the number of neurons bearing neurites within two days of contact between the two cell types. Neuronal death and phagocytosis were also directly observed in video recordings of living cultures. This toxicity involved the production by brain macrophages of reactive oxygen intermediates, as shown by the protective effect of catalase, a scavenger of H2O2. In addition, the respiratory bursts of brain macrophages were stimulated in the presence of neurons. These results suggest that brain macrophages could favour the appearance of neuroregressive events which occur either during neurogenesis or in neurodegenerative diseases, implying intracerebral recruitment of mononuclear phagocytes.
202 citations
TL;DR: A l 'échelle du neu rone, des observations récentes montrent that le macro phage peut faire office of tueur , mais il peut aussi, dans d' autres conditions, favoriser la survie des cellu les ou des remaniements de leurs arborisations axonales.
Abstract: Phénotype particulier de la microglie , les macrophages cérébraux sont physiologiquement présents dans le système nerveux immature et réapparaissent dans le parenchyme cérébt.:al adulte lors d' affections inflamma toires ou neurodégénératives . Ils se distinguent des cel lules microgliales ramifiées observées dans le tissu sain selon plusieurs critères structuraux ou fonctionnels , dont l ' activité de phagocytose. Par leurs interactions avec les différents types de cellules nerveuses, les macrophages cérébraux sont impliqués dans des processus de dégra dation ou de remodelage tissulaire . A l 'échelle du neu rone, des observations récentes montrent que le macro phage pe_ut faire office de tueur , mais il peut aussi, dans d' autres conditions , favoriser la survie des cellu les ou des remaniements de leurs arborisations axonales .
4 citations