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Brigitte L. Thériault
Researcher at Ontario Institute for Cancer Research
Publications - 24
Citations - 874
Brigitte L. Thériault is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Retinoblastoma & Ovarian cancer. The author has an hindex of 12, co-authored 20 publications receiving 763 citations. Previous affiliations of Brigitte L. Thériault include University Health Network & Princess Margaret Cancer Centre.
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Journal ArticleDOI
BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells.
TL;DR: Treatment of OvCa cells with BMP4 produced morphological alterations and increased cellular adhesion, motility and invasion, suggesting a link between autocrine BMP signalling mediated through the Rho GTPase family and Snail- and Slug-induced EMT that may collectively contribute to aggressive OvCa behaviour.
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Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients
TL;DR: The laboratory has refined the technique for isolating primary cultures of normal human ovarian surface epithelial cells by combining two different protocols involving the enzymatic and mechanical removal of OSE cells from ovarian biopsies by including optional steps for the immediate preparation of ascites-derived EOC cells to be used for subsequent cytological analyses.
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The genomic landscape of retinoblastoma: a review.
TL;DR: A recent review as discussed by the authors outlines the current understanding of the genomic, genetic and epigenetic changes in retinoblastoma, highlighting recent genome-wide analyses that have identified exciting candidate genes worthy of further validation as potential prognostic and therapeutic targets.
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Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer.
Brigitte L. Thériault,Sanja Pajovic,Marcus Q. Bernardini,Marcus Q. Bernardini,Patricia Shaw,Brenda L. Gallie +5 more
TL;DR: Dependence of OvCa cells on Kif14 for maintenance of in vitro colony formation suggests a role of KIF14 in promoting a tumorigenic phenotype, beyond its known role in proliferation.
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KIF14 negatively regulates Rap1a–Radil signaling during breast cancer progression
Syed M. Ahmed,Brigitte L. Thériault,Maruti Uppalapati,Catherine W.N. Chiu,Brenda L. Gallie,Sachdev S. Sidhu,Stephane Angers +6 more
TL;DR: The kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules.