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Bruno Simini
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 12
Citations - 917
Bruno Simini is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Intensive care & Intensive care unit. The author has an hindex of 10, co-authored 12 publications receiving 874 citations.
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Journal ArticleDOI
Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial.
Guido Bertolini,Gaetano Iapichino,Danilo Radrizzani,Rebecca Facchini,Bruno Simini,P. Bruzzone,G. Zanforlin,Gianni Tognoni +7 more
TL;DR: The results show that enteral immunonutrition, compared to PN, may be associated with excess mortality in patients with severe sepsis.
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Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study.
Nicola Latronico,Guido Bertolini,Bruno Guarneri,Marco Botteri,Elena Peli,Serena Andreoletti,Paola Bera,Davide Luciani,Anna Nardella,Elena Vittorielli,Bruno Simini,Andrea Candiani +11 more
TL;DR: A peroneal CMAP reduction below two standard deviations of normal value accurately identifies patients with CRIMYNE, and these should have full neurological and neurophysiological evaluations before discharge from the acute hospital.
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The relationship between labour cost per patient and the size of intensive care units: a multicentre prospective study.
Guido Bertolini,Carlotta Rossi,Luca Brazzi,Danilo Radrizzani,Giancarlo Rossi,Enrico Arrighi,Bruno Simini +6 more
TL;DR: The findings suggest that ICUs with less than about 12 beds are not cost-effective, and ICU characteristics that predict labour costs per patient are identified.
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Volume of activity and occupancy rate in intensive care units. Association with mortality.
Gaetano lapichino,Luciano Gattinoni,Danilo Radrizzani,Bruno Simini,Guido Bertolini,Luca Ferla,Giovanni Mistraletti,Francesca Porta,Dinis Reis Miranda +8 more
TL;DR: Intensive care patients, whatever their level of risk, are best treated where more high-risk patients are treated, and the higher the ICU occupancy rate, the higher is the mortality.
Journal ArticleDOI
Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trial
D Radrizzani,Guido Bertolini,Rebecca Facchini,Bruno Simini,P. Bruzzone,G. Zanforlin,Gianni Tognoni,G. Iapichino +7 more
TL;DR: Compared to parenteral nutrition iEN appears to be beneficial in critical patients without severe sepsis or septic shock, and parenTERal nutrition in these patients should be abandoned, at least when enteral nutrition can be administered, even at an initial low caloric content.