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Byeongwoon Song
Researcher at Harvard University
Publications - 25
Citations - 3124
Byeongwoon Song is an academic researcher from Harvard University. The author has contributed to research in topics: TRIM5alpha & Capsid. The author has an hindex of 22, co-authored 24 publications receiving 3048 citations.
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Journal ArticleDOI
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor
Matthew Stremlau,Michel Perron,Mark Lee,Yuan Li,Byeongwoon Song,Hassan Javanbakht,Felipe Diaz-Griffero,Donovan J. Anderson,Wesley I. Sundquist,Joseph Sodroski +9 more
TL;DR: It is demonstrated that TRIM5alpha variants from Old World monkeys specifically associate with the HIV type 1 (HIV-1) capsid and that this interaction depends on the TRIM 5alpha B30.2 domain.
Journal ArticleDOI
TRIM5α mediates the postentry block to N-tropic murine leukemia viruses in human cells
TL;DR: It is shown that human TRIM5alpha is both necessary and sufficient for the restriction of N-MLV in human cells, and species-specific variation in TRIM 5alpha governs its ability to block infection by diverse retroviruses.
Journal ArticleDOI
Retrovirus Restriction by TRIM5α Variants from Old World and New World Primates
Byeongwoon Song,Hassan Javanbakht,Michel Perron,Do Hyun Park,Matthew Stremlau,Joseph Sodroski +5 more
TL;DR: Variation in TRIM5α proteins among primate species accounts for the observed patterns of postentry restrictions in cells from these animals.
Journal ArticleDOI
The B30.2(SPRY) Domain of the Retroviral Restriction Factor TRIM5α Exhibits Lineage-Specific Length and Sequence Variation in Primates
Byeongwoon Song,Bert Gold,Colm O'hUigin,Hassan Javanbakht,Xing Li,Matthew Stremlau,Cheryl A. Winkler,Michael Dean,Joseph Sodroski +8 more
TL;DR: The results suggest that occasional, complex changes were incorporated into the TRIM5α B30.2 domain at discrete time points during the evolution of primates, based on the appearance of particular endogenous retroviruses in primate genomes.
Journal ArticleDOI
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5
Felipe Diaz-Griffero,Xing Li,Hassan Javanbakht,Byeongwoon Song,Sohanya Welikala,Matthew Stremlau,Joseph Sodroski +6 more
TL;DR: TRIM5alpha levels in the cell are maintained by continuous synthesis and rapid proteasome-mediated degradation, imbalances in which result in the formation of pre-aggresomal cytoplasmic bodies.