C
C. A. Wells
Publications - 2
Citations - 542
C. A. Wells is an academic researcher. The author has contributed to research in topics: Islet & Pancreas. The author has an hindex of 2, co-authored 2 publications receiving 518 citations.
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Journal Article
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.
A Clark,C. A. Wells,I. D. Buley,J. K. Cruickshank,R. I. Vanhegan,David R Matthews,Garth J. S. Cooper,Rury R. Holman,R. C. Turner +8 more
TL;DR: The impaired insulin secretion in Type 2 diabetes may be due to a decrease in B-cells and to disruption of the islet structure by amyloid, and the increase in A-cells may contribute to the hyperglucagonaemia and hyperglycaemia of Type 2 Diabetes.
Journal Article
Pancreatic islet amyloid and elevated proinsulin secretion in familial maturity-onset diabetes.
TL;DR: Elevated proinsulin levels in a patient with islet-amyloid is consistent with the hypothesis that amyloid may be derived from abnormal beta-cell secretion.