A
A Clark
Researcher at University of Oxford
Publications - 61
Citations - 4003
A Clark is an academic researcher from University of Oxford. The author has contributed to research in topics: Islet & Amyloid. The author has an hindex of 27, co-authored 59 publications receiving 3802 citations.
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Journal ArticleDOI
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
TL;DR: A peptide, of calculated molecular mass 3905 Da, that was a major protein component of amyloid-rich pancreatic extracts of three type 2 diabetic patients is described, indicating that these peptides are related in evolution.
Journal Article
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.
A Clark,C. A. Wells,I. D. Buley,J. K. Cruickshank,R. I. Vanhegan,David R Matthews,Garth J. S. Cooper,Rury R. Holman,R. C. Turner +8 more
TL;DR: The impaired insulin secretion in Type 2 diabetes may be due to a decrease in B-cells and to disruption of the islet structure by amyloid, and the increase in A-cells may contribute to the hyperglucagonaemia and hyperglycaemia of Type 2 Diabetes.
Journal ArticleDOI
Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes.
A Clark,Claire E. Lewis,Antony C. Willis,Garth J. S. Cooper,John F. Morris,Kenneth B.M. Reid,Robert C Turner +6 more
TL;DR: Results suggest that islet amyloid contains diabetes-associated peptide, which may originate from B-cells, which is likely to impair islet function and may be a causal factor in the development of type-2 diabetes.
Journal Article
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
Melissa F. Brereton,Michaela Iberl,Kenju Shimomura,Quan Zhang,Peter Proks,A A Adriaenssens,Ioannis Spiliotis,W Dace,Katia K. Mattis,Fiona M. Gribble,Frank Reimann,A Clark,Patrik Rorsman,F M Ashcrot +13 more
TL;DR: It is shown that β-cell-specific expression of a human activating KATP channel mutation in adult mice leads to rapid diabetes and marked alterations in islet morphology, ultrastructure and gene expression.
Journal ArticleDOI
Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population
TL;DR: Islet amyloid appears to precede the development of overt diabetes in Macaca mulatta rhesus monkeys and is likely to be a factor in the destruction of islet cells and onset of hyperglycaemia.