C. B. Guedes

TL;DR: In this article , the role of NRF2 in ferroptosis modulation in glioblastoma cells was analyzed, and it was shown that high levels of NN2 result in collateral sensitivity on glioma via the expression of its pro-ferroptotic target ABCC1 , which contributes to GSH depletion when the system xc − is blocked by Erastin.

TL;DR: An overview of the mechanisms of the iron-dependent cell death and the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway are presented and focused on new ferroPTosis-inducing compounds for glioma treatment.

TL;DR: In this article , the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni egg-laying in vitro were investigated. And they found that crosstalk involving hTNF and parasite signaling plays a role in the fine-scale regulation of the worm's metabolism and physiology, and points to new strategies for disease control.

TL;DR: In this paper , the effects of human tumor necrosis factor alpha (hTNF-α) on Schistosoma mansoni egg-laying in vitro were investigated. And they found that crosstalk involving hTNF and parasite signaling plays a role in the fine-scale regulation of the worm's metabolism and physiology, and points to new strategies for disease control.

TL;DR: In this paper , a review highlights the research that is demonstrating how NRF2 hyperactivation creates an environment that favors the survival of malignant cells and protects against oxidative stress and TMZ.