C
C. Guidali
Researcher at University of Insubria
Publications - 14
Citations - 1762
C. Guidali is an academic researcher from University of Insubria. The author has contributed to research in topics: Prefrontal cortex & Endocannabinoid system. The author has an hindex of 12, co-authored 14 publications receiving 1596 citations.
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Journal ArticleDOI
Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TL;DR: The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.
Journal ArticleDOI
Role in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex
Tiziana Rubino,Natalia Realini,Chiara Castiglioni,C. Guidali,Daniela Viganò,Emanuela Marras,Stefania Petrosino,Gianpaolo Perletti,Mauro Maccarrone,V. Di Marzo,Daniela Parolaro +10 more
TL;DR: Findings support an anxiolytic role for physiological increases in AEA in the PFC, whereas more marked increases or decreases of this endocannabinoid might lead to an anxiogenic response due to TRPV1 stimulation or the lack of CB1 activation, respectively.
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Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood.
Tiziana Rubino,Natalia Realini,Daniela Braida,Sandra Guidi,Valeria Capurro,Daniela Viganò,C. Guidali,Marta Pinter,Mariaelvina Sala,Renata Bartesaghi,Daniela Parolaro +10 more
TL;DR: The data suggest that THC pretreated rats may establish less synaptic contacts and/or less efficient synaptic connections throughout the hippocampus and this could represent the molecular underpinning of the cognitive deficit induced by adolescent THC treatment.
Journal ArticleDOI
CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.
TL;DR: The results suggest that while a mild activation of CB1 receptors in the prefrontal cortex and ventral hippocampus attenuates anxiety, a slight CB1 receptor stimulation in the amygdala results in an anxiogenic-like response.
Journal ArticleDOI
The endocannabinoid system and psychiatric disorders.
TL;DR: SR141716A and cannabidiol show the most constant antipsychotic properties in dopamine- and glutamate-based models of schizophrenia, with profiles similar to an atypical antipsychotics drug.