/pdf/are-alkyne-reductions-chemo-regio-and-stereoselective-enough-2k025fyx4w.pdf

Are alkyne reductions chemo-, regio-, and stereoselective enough to provide pure (Z)-olefins in polyfunctionalized bioactive molecules?

Carotenoids Rosana Álvarez,† Beleń Vaz,† Hinrich Gronemeyer,‡ and Ángel R. de Lera*,† †Departamento de Química Orgańica, Centro de Investigacioń Biomed́ica (CINBIO), and Instituto de Investigacioń Biomed́ica de Vigo (IBIV), Universidade de Vigo, 36310 Vigo, Spain ‡Department of Functional Genomics and Cancer, Institut de Geńet́ique et de Biologie Molećulaire et Cellulaire (IGBMC)/CNRS/INSERM/ULP, BP 10142, 67404 Illkirch Cedex, C. U. de Strasbourg, France

Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids

Carotenoid processing with supercritical fluids.

Retinoids have and will continue to revolutionize dermatologic therapy in a manner analogous to the development of topical corticosteroids Isotretinoin, for example, has made nodulocystic scarring acne an eminently treatable condition The dermatologic armamentarium now includes a powerful new agent, etretinate, which will radically change the approach to psoriasis (and other keratinizing disorders) Although each new retinoid is developed with the aim of maximizing specific therapeutic effects and minimizing toxicity, the fact remains that the major side effects of retinoid treatment are those of hypervitaminosis A syndrome Optimal clinical utilization of new retinoids is best accomplished by an assessment of what is currently known about retinol absorption, metabolism and organ-specific effects, as well as by a thorough understanding of hypervitaminosis A syndrome In this paper, hypervitaminosis A syndrome is reviewed as a paradigm of retinoid side effects (J Am Acad Dermatol 1987;16:1027-39)

Hypervitaminosis A syndrome: a paradigm of retinoid side effects

Since the discovery of vitamin A as a fat-soluble growth factor in the early part of the century, research into carotenoids and retinoids has attracted the attention of many scientists. These two groups of compounds are still being actively studied all over the world since many gaps in knowledge exist and new frontiers are being pursued. Recent developments in studies into the possible roles of carotenoids and retinoids beyond their classical functions in vision have created a great deal of excitement in the biomedical community. This review covers a wide range of topics pertaining to these two closely related compounds. Particular emphasis is given to the functions of these compounds and their roles in human nutrition. Various aspects of vitamin A deficiency and studies on carotenoids and retinoids in cancer development and prevention are reviewed in some detail.

Carotenoids and retinoids in human nutrition

Es wird eine Totalsynthese des β-Carotins beschrieben, welche zum kristallisierten, reinen Farbstoff fuhrt.

C. H. Eugster

Papers

Synthese von Carotinoiden II. Totalsynthese des β-Carotins I