C
C. McMartin
Researcher at Ciba Specialty Chemicals
Publications - 20
Citations - 749
C. McMartin is an academic researcher from Ciba Specialty Chemicals. The author has contributed to research in topics: Guanethidine & Peptide sequence. The author has an hindex of 13, co-authored 20 publications receiving 745 citations.
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Journal ArticleDOI
Use of octadecasilyl-silica for the extraction and purification of peptides in biological samples. Application to the identification of circulating metabolites of corticotropin-(1-24)-tetracosapeptide and somatostatin in vivo.
TL;DR: Somatostatin was rapidly cleaved in vivo and in vitro to a single product, which probably retains biological activity and is likely to be inactivated once it leaves the circulation.
Journal ArticleDOI
A rapid method, using octadecasilyl-silica, for the extraction of certain peptides from tissues.
TL;DR: Recoveries of corticotropins and somatostatin added to a variety of tissues were quantitative, and the peptides undamaged as determined by high-pressure liquid chromatography.
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The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.
TL;DR: The isolation of an adrenocorticotrophic hormone from extracts of the pars distalis of the pituitary of the dogfish Squalus acanthias supported the view that ACTH as well as having a distinct biological role of its own is also the precursor of alpha-MSH.
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Measurement of the dynamics of stimulation and inhibition of steroidogenesis in isolated rat adrenal cells by using column perfusion
P. J. Lowry,C. McMartin +1 more
TL;DR: The rapid response to cyclic AMP makes it unlikely that steroid production is induced as a result of initiation of protein synthesis, and suggests that the labile protein plays an obligatory but permissive role in the development of the response.
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Structural studies of α-melanocyte-stimulating hormone and a novel β-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias
TL;DR: A melanocyte-stimulating hormone (MSH) has been isolated from extracts of the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias by gel-filtration and ion-exchange chromatography and revealed to be a tridecapeptide which is identical with the N-terminal sequence of dogfish adrenocorticotrophin.