C
C. McSharry
Researcher at University of Glasgow
Publications - 35
Citations - 3278
C. McSharry is an academic researcher from University of Glasgow. The author has contributed to research in topics: Asthma & House dust mite. The author has an hindex of 22, co-authored 35 publications receiving 3075 citations.
Papers
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Journal ArticleDOI
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation
Mariola Kurowska-Stolarska,Bartosz Stolarski,Peter Kewin,Grace Murphy,Christopher Corrigan,Sun Ying,Nick Pitman,Ananda S. Mirchandani,Batika Rana,Nico van Rooijen,Malcolm Shepherd,C. McSharry,Iain B. McInnes,Damo Xu,Foo Y. Liew +14 more
TL;DR: It is demonstrated here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation.
Journal ArticleDOI
Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
George W Chalmers,Kirsten J. MacLeod,Stuart A. Little,L.J. Thomson,C. McSharry,Neil C. Thomson +5 more
TL;DR: Active cigarette smoking impairs the efficacy of short term inhaled corticosteroid treatment in mild asthma, and this finding has important implications for the management of patients with mild asthma who smoke.
Journal ArticleDOI
CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice
TL;DR: In vitro and in vivo evidence is provided that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these Regulatory T cells have a profound therapeutic potential against diseases induced by both Th2 and Th1 cells in vivo.
Journal ArticleDOI
High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity.
Stuart A. Little,Michael Sproule,M D Cowan,Kirsten J. MacLeod,Michele Robertson,Janet G Love,George W Chalmers,C. McSharry,Neil C. Thomson +8 more
TL;DR: The airway wall is thickened in more severe asthma and is associated with gas transfer coefficient, but this thickening does not relate directly to irreversible airflow obstruction as measured with FEV1.
Journal Article
Hypersensitivity pneumonitis: current concepts
TL;DR: Hypersensitivity pneumonitis, or extrinsic allergic alveolitis, is due to a hypersensitivity reaction after repeated inhalation of finely dispersed antigens, mainly organic particles or low molecular weight chemicals.