S
Sun Ying
Researcher at Capital Medical University
Publications - 133
Citations - 17189
Sun Ying is an academic researcher from Capital Medical University. The author has contributed to research in topics: Eosinophil & Cytokine. The author has an hindex of 54, co-authored 131 publications receiving 16335 citations. Previous affiliations of Sun Ying include King's College London & National Institutes of Health.
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
Journal ArticleDOI
Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.
Qutayba Hamid,May Azzawi,Sun Ying,Redwan Moqbel,Andrew J. Wardlaw,Christopher Corrigan,B. Bradley,Stephen R. Durham,J.V. Collins,Peter K. Jeffery +9 more
TL;DR: Evidence is provided for the cellular localization of IL-5 mRNA in the bronchial mucosa of asthmatics and supports the concept that this cytokine regulates eosinophil function in Bronchial asthma.
Journal ArticleDOI
Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.
Sun Ying,Brian J. O'Connor,Jonathan Ratoff,Qiu Meng,K. Mallett,David J. Cousins,Douglas S. Robinson,Guizhen Zhang,Jisheng Zhao,Tak H. Lee,Christopher Corrigan +10 more
TL;DR: The data implicate TSLP, TARC/ CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis, which may act partly through selective development and retention, or recruitment of Th2 cells bearing their receptors.
Journal ArticleDOI
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
P. Flood-Page,Andrew Menzies-Gow,Simon Phipps,Sun Ying,A. Wangoo,Mara S. Ludwig,Neil Barnes,Douglas S. Robinson,A. Barry Kay +8 more
TL;DR: Treating asthmatics with anti-IL-5 antibody, which specifically decreased airway eosinophil numbers, significantly reduced the expression of tenascin, lumican, and procollagen III in the bronchial mucosal RBM when compared with placebo.
Journal ArticleDOI
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation
Mariola Kurowska-Stolarska,Bartosz Stolarski,Peter Kewin,Grace Murphy,Christopher Corrigan,Sun Ying,Nick Pitman,Ananda S. Mirchandani,Batika Rana,Nico van Rooijen,Malcolm Shepherd,C. McSharry,Iain B. McInnes,Damo Xu,Foo Y. Liew +14 more
TL;DR: It is demonstrated here that IL-33/ST2 plays a significant role in the amplification of AAM polarization and chemokine production which contribute to innate and Ag-induced airway inflammation.