C. T. Dollery

TL;DR: The left lung from a dog was removed, ventilated with negative pressure, and perfused with venous blood to establish pulmonary arterial, venous, and alveolar pressures that could be varied over a large range.

TL;DR: Evidence that increased vascular resistance in an isolated dog lung made with radioactive xenon was caused by perivascular edema consisted of the general correlation with interstitial edema, the regional distribution of the effect, the sensitivity to the arteriovenous pressure difference, the effect of certain infusions particularly hypertonic urea, and the demonstration of edema around the small arteries and veins in rapidly frozen sections.

TL;DR: Using radioactive oxygen (O15), carbon monoxide and carbon dioxide with external counting over the chest, it is possible to measure perfusion and diffusion per unit of lung volume and these changes are consistent with the radiological and pathological changes in the pulmonary vascular tree in mitral stenosis.

TL;DR: It was concluded that although the over-all pressure-flow relations of the whole lung were complicated, the flow through individual vessels could be accounted for by the simple mechanical effects of pressures inside and outside the vessels.

TL;DR: Carbon dioxide labeled with oxygen 15 has been used to measure regional blood flow in the lung by counting over the chest during a short breath-holding period following a single breath of the gas.