C
Cai Wu
Researcher at Tsinghua University
Publications - 1
Citations - 74
Cai Wu is an academic researcher from Tsinghua University. The author has contributed to research in topics: Deubiquitinating enzyme & Small molecule. The author has an hindex of 1, co-authored 1 publications receiving 58 citations.
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Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
Yiwei Wang,Yuxuan Jiang,Shan Ding,Jiawang Li,Ningjing Song,Yujing Ren,Danning Hong,Cai Wu,Bin Li,Feng Wang,Wei He,Jiawei Wang,Ziqing Mei +12 more
TL;DR: This work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade, as showcased by the discovery of IU1-248 which is 10-fold more potent than IU1.