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Yiwei Wang
Researcher at Tsinghua University
Publications - 2
Citations - 148
Yiwei Wang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Deubiquitinating enzyme & Small molecule. The author has an hindex of 2, co-authored 2 publications receiving 119 citations.
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Journal ArticleDOI
Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
Yiwei Wang,Yuxuan Jiang,Shan Ding,Jiawang Li,Ningjing Song,Yujing Ren,Danning Hong,Cai Wu,Bin Li,Feng Wang,Wei He,Jiawei Wang,Ziqing Mei +12 more
TL;DR: This work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade, as showcased by the discovery of IU1-248 which is 10-fold more potent than IU1.
Journal ArticleDOI
Structure of an endogenous yeast 26S proteasome reveals two major conformational states
Bai Luan,Xiuliang Huang,Jianping Wu,Ziqing Mei,Yiwei Wang,Xiaobin Xue,Chuangye Yan,Jiawei Wang,Daniel Finley,Yigong Shi,Feng Wang +10 more
TL;DR: Cryo-EM structures of the endogenous 26S proteasome from Saccharomyces cerevisiae reveal two distinct conformational states, which appear to correspond to different states of ATP hydrolysis and substrate binding, and serve as a molecular basis for mechanistic understanding of proteAsome function.