Showing papers by "Caitriona M. O'Driscoll published in 2020"
TL;DR: By focusing on successfully commercialised drugs, this review provides improved understanding of links between drug properties and successful SD/LBF approaches, providing a framework for guiding pharmaceutical development on formulation approaches.
17 citations
TL;DR: An in vitro tool for predicting drug solubility and dissolution in intestinal fluids of patients with Celiac disease (CED) is developed and developed based on published information and a Design of Experiment (DoE) approach.
8 citations
TL;DR: A high risk was related to drug ionization properties and lipophilicity in the current study with all investigated drugs showing differences in solubility in biorelevant media based on UC patients compared to healthy subjects.
5 citations
TL;DR: Estimation of the stability of amphiphilic cyclodextrin-based nanoparticles containing insulin glulisine indicated that potential exists for further development of the formulation to simultaneously achieve prolonged stability and therapeutic efficacy.
Abstract: Long-term stability is one of the main challenges for translation of therapeutic proteins into commercially viable biopharmaceutical products. During processing and storage, proteins are susceptibl...
3 citations