Showing papers in "Drug Development and Industrial Pharmacy in 2020"
TL;DR: Baicalein and quercetin in HSBDF may regulate multiple signaling pathways through ACE2, which might play a therapeutic role on COVID-19.
Abstract: Huashi Baidu formula (HSBDF) was developed to treat the patients with severe COVID-19 in China. The purpose of this study was to explore its active compounds and demonstrate its mechanisms against ...
127 citations
TL;DR: An overview of the SLS printing method, excipient requirements, process monitoring, quality defects, regulatory aspects, and potential pharmaceutical applications is provided.
Abstract: Food and Drug Administration (FDA) has approved a drug product (Spritam®) and many medical devices manufactured by three-dimensional printing (3DP) processes for human use. There is immense potential to print personalized medicines using 3DP. Many 3DP methods have been reported in the literature for pharmaceutical applications. However, selective laser sintering (SLS) printing has remained least explored for pharmaceutical applications. There are many advantages and challenges in adopting a SLS method for fabrication of personalized medicines. Solvent-free nature, availability of FDA approved thermoplastic polymer/excipients (currently used in hot melt-extrusion process), minimal/no post-processing step, etc. are some of the advantages of the SLS printing process. Major challenges of the technology are requirement of at least one thermoplastic component in the formulation and thermal stability of drug and excipients. This review provides an overview of the SLS printing method, excipient requirements, process monitoring, quality defects, regulatory aspects, and potential pharmaceutical applications.
74 citations
TL;DR: Despite the fact that many benefits come with the usage of HA, its deficiencies and potential side effects must be addressed before the translation to the clinical domain is pursued.
Abstract: The synthetic analogue to biogenic apatite, hydroxyapatite (HA) has a number of physicochemical properties that make it an attractive candidate for diagnosis, treatment of disease and augmentation of biological tissues. Here we describe some of the recent studies on HA, which may provide bases for a number of new medical applications. The content of this review is divided to different medical application modes utilizing HA, including tissue engineering, medical implants, controlled drug delivery, gene therapies, cancer therapies and bioimaging. A number of advantages of HA over other biomaterials emerge from this discourse, including (i) biocompatibility, (ii) bioactivity, (iii) relatively simple synthesis protocols for the fabrication of nanoparticles with specific sizes and shapes, (iv) smart response to environmental stimuli, (v) facile functionalization and surface modification through noncovalent interactions, and (vi) the capacity for being simultaneously loaded with a wide range of therapeutic agents and switched to bioimaging modalities for uses in theranostics. A special section is dedicated to analysis of the safety of particulate HA as a component of parenterally administrable medications. It is concluded that despite the fact that many benefits come with the usage of HA, its deficiencies and potential side effects must be addressed before the translation to the clinical domain is pursued. Although HA has been known in the biomaterials world as the exemplar of safety, this safety proves to be the function of size, morphology, surface ligands and other structural and compositional parameters defining the particles. For this reason, each HA, especially when it comes in a novel structural form, must be treated anew from the safety research angle before being allowed to enter the clinical stage.
52 citations
TL;DR: Good linear relationship between theoretical model volume and drug content and good dose accuracy indicate that 3DP is a suitable method for preparing individualized ODFs.
Abstract: Orodispersible films (ODFs) are promising drug delivery systems for customized medicines as it provide an alternative approach to increase consumer acceptance by advantages of rapid dissolution and...
50 citations
TL;DR: It is concluded that cisplatin-loaded M1 exosomes are potentially powerful new tools for the delivery of chemotherapeutics to treat cancers regardless of drug resistance.
Abstract: Objective: To assess the feasibility of an exosome-based drug delivery platform for the potent chemotherapeutic agent cisplatin to treat ovarian cancer.Significance: Exosomes have recently been use...
47 citations
TL;DR: The present work denotes that GSE constitutes a good source of PC’s and will be useful in the prevention and treatment of free radical related diseases.
Abstract: The main objective of this work was to formulate a nanodispersion containing grape seed extract and analyzed its release profile, antioxidant potential of the prepared formulations. The grape seed ...
41 citations
TL;DR: In this paper, the authors focused mainly on the development of aceclofenac (AF) loaded transfersomal gel (AF-TG) to minimize the frequency of oral dosing during the treatment of osteoarthritis.
Abstract: The present investigation focused mainly on the development of aceclofenac (AF) loaded transfersomal gel (AF-TG) to minimize the frequency of oral dosing during the treatment of osteoarthritis, rhe...
37 citations
TL;DR: Vaginal use of metronidazole-loaded nanofibers has been shown to be a potential drug delivery system for the treatment of BV.
Abstract: Objective: To develop and characterize innovative vaginal dosage forms for the treatment of bacterial vaginosis (BV).Significance: This study is the first comparative evaluation of the metronidazole (MET)-loaded polyvinylpyrrolidone (PVP) nanofiber formulations on BV treatment. Vaginal nanofibers are one of the potential innovative dosage forms for BV treatment because of their flexible, mucoadhesive, and easy application in vaginal application which can be applied by the mucosal route.Methods: Blank and MET-loaded PVP solutions were prepared at three different concentrations (10, 12.5, 15%) for produce nanofiber. The suitability of the viscosities, surface tensions, and conductivity values of the solutions used to produce nanofibers for the electrospinning process has been evaluated. Scanning electron microscopy, mucoadhesion, permeability, Fourier transform infrared spectroscopy, differential scanning calorimetry, and drug release tests were performed to reveal the physical, chemical, and pharmaceutical properties of the nanofibers. Mechanical properties, and contact angle of the fibers were also determined. Gel and solution formulations containing MET were prepared for comparative studies.Results: All polymer solutions were found to be suitable for electrospinning process. PVP concentration directly affected nanofiber diameter, mechanical, and mucoadhesion properties of nanofibers. The release profiles of the drug from the nanofibers were similar for all concentration of PVP and release from the fibers was rapid. The permeability coefficient of MET from nanofibers was increased more than gel and solution formulations.Conclusions: Vaginal use of MET-loaded nanofibers has been shown to be a potential drug delivery system for the treatment of BV.
34 citations
TL;DR: Results indicate that the novel PNP developed in this work are safe and promising carriers for controlled delivery of RES at the colon.
Abstract: Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact on drug release rates and permeability were evaluated using Caco-...
32 citations
TL;DR: It is suggested that niosomal delivery could be considered as a promising strategy for the delivery of poor water-soluble drugs to cancer cells by showing good physicochemical and biological properties than free drug.
Abstract: The objective of this study was to use nano-niosomal formulations to deliver simvastatin as a poor-water soluble drug into breast cancer cells. Our study focused on the problem associated with poor...
31 citations
TL;DR: NARG-loaded NPs gave ameliorated anticancer effect over plain NARG, according to in vitro, optimization, characterization, and cytotoxic studies of NAR nanoparticles (NPs) to against pancreatic cancer.
Abstract: Objective: In vitro, optimization, characterization, and cytotoxic studies of NAR nanoparticles (NPs) to against pancreatic cancer.Method: The sonication tailored Naringenin (NARG)-loaded poly (lac...
TL;DR: Current approaches of altering drug delivery when manufacturing 3D printed dosage forms that vary in their drug release profiles and characteristics are discussed, to developing and delivering patient-specific treatments.
Abstract: Three-dimensional (3D) printing has recently appeared as one of the most promising additive manufacturing techniques to fabricate 3D objects, with uses spanning from engineering prototyping to medicines and cell-laden models for biomedical applications. Regardless of the type and underlying theory, 3D printing techniques involve the deposition of materials such as thermoplastic polymers or hydrogel in sequential layers one onto another to produce a 3D object. 3D printing has recently gained momentum in developing various drug delivery systems for pharmaceutical applications which is reflected by the exponential rise in the number of published papers and patents in recent years. Whilst the future of 3D printing techniques is bright, various obstacles need to be overcome before it can be applied practically in commercial-scale production. This review article discusses current approaches of altering drug delivery when manufacturing 3D printed dosage forms that vary in their drug release profiles and characteristics. Such achievements correspond to developing and delivering patient-specific treatments. With each type of 3D printing application, there are great benefits, and these are highlighted, however, a critical discussion will underline the limitations and challenges associated with 3D printing.
TL;DR: The presented methodology provided a proof-of-concept formulation approach for the development of personalized mucoadhesive films for the buccal delivery of a thermolabile model drug.
Abstract: The inkjet printing (IP) and fused deposition modeling (FDM) technologies have emerged in the pharmaceutical field as novel and personalized formulation approaches Specific manufacturing factors m
TL;DR: In this paper, the choice of a desirable solvent/solvent system is fundamental for optimization of electrospinning by altering the rheological and electrostatic properties of the polymer solutions.
Abstract: Objective: The choice of a desirable solvent/solvent system is fundamental for optimization of electrospinning by altering the rheological and electrostatic properties of the polymer solutions.Meth...
TL;DR: MOP can be developed as a potential ophthalmic drug delivery system in delivering the model drug, pilocarpine HCl across the corneal membrane according to its physical and mechanical properties.
Abstract: Context: Enhacing the ocular bioavailability of drugs after their topical application is a challenge.Objective: The objective of the study was to design, fabricate, and investigate the effectivenes...
TL;DR: The findings have shown the selected formulation of G4 PAMAM dendrimer-Palmitic acid core-shell nanoparticle-containingCurcumin as antistress therapeutics to maximize the bioavailability of curcumin.
Abstract: Despite poor bioavailability of the drug and in vivo stability, curcumin has been reported for many pharmacological activities. Considering the potential of dendrimers as a drug delivery sy...
TL;DR: Investigations showed that that the controlled drug release and gastro-protective drug delivery of NSAIDS was achieved using CAP-co-poly(HEMA) microgel particles.
Abstract: Objectives: The study aimed to develop safe, effective, and targeted drug delivery system for administration of nonsteroidal anti-inflammatory drugs (NSAIDs) in the form of microgels. We de...
TL;DR: A dry powder inhaler dosage form containing gefitinib loaded glucosamine targeted solid lipid nanopaticles (Gef-G-SLNs) to locally transfer anticancer agent to the lung tumor shows promising drug delivery to treatment of lung cancer.
Abstract: Gefitinib as an epidermal growth factor receptor tyrosine kinase inhibitor has strong potential in lung cancer therapy However, a major challenge of using gefitinib is its toxicities In the prese
TL;DR: It was concluded thatSNEDDS have offered sufficient stability as well as dissolution rate of DHA and absence of drug precipitation, phase separation, and turbidity during thermodynamic stability studies indicated that the developed SNEDDS were stable.
Abstract: Development of self-nanoemulsifying drug delivery systems (SNEDDS) of docosahexaenoic acid (DHA) is reported with the aim to achieve enhanced dissolution rate. The optimized composition of liquid S...
TL;DR: FLB-loaded NPs seem to be a promising extended-release drug delivery system for oral administration with a low dose and high efficiency and the in vivo anti-inflammatory activity results indicated that A6 coded formulation was showed significantly good anti- inflammatory potential at low dose.
Abstract: Objective: The effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loa...
TL;DR: Preformulation studies and a statistical hybrid-design approach was effectively applied to incorporate IBU in NLCs, resulting in a robust ophthalmic formulation with superior physicochemical properties.
Abstract: The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a qualit...
TL;DR: In rabbits’ eyes, this gel was free of toxic and irritant effects and reduced intraocular pressure over a period of three days, which was significantly longer than that of commercial latanoprost eye drops, which may find applications in glaucoma management.
Abstract: Objective: Glaucoma is a leading cause of irreversible blindness worldwide. Whereas latanoprost is one of the most effective drugs in glaucoma treatment, its eye drops need frequent application lea...
TL;DR: Developing nitrendipine nanoemulsion gel overcomes the limitation of low penetration and accentuate permeation through albino Wistar rat skin and could be utilized as a potential carrier for transdermal delivery of nitrenderipine.
Abstract: Objective: The purpose of present research was to develop and statistically optimize nitrendipine nanoemulsion gel for transdermal delivery using box-behnken statistical design.Method: The ...
TL;DR: A novel low-temperature 3 D printing technique is introduced and characterized through a parametric printability study to fabricate poly-lactic-co-glycolic acid (PLGA) constructs using methyl ethyl ketone (MEK) as a solvent, which can be used for the development of drug-eluting implants.
Abstract: In this paper, a novel low-temperature 3 D printing technique is introduced and characterized through a parametric printability study to fabricate poly-lactic-co-glycolic acid (PLGA) constructs usi...
TL;DR: Histopathological evaluations demonstrated that RA-CH-G-NPOs showed significantly enhanced wound contraction, enhanced cell adhesion, epithelial migration, and high hydroxyproline content leading to faster and more efficient collagen synthesis as compared to plain carbopol, plain RA and controls, making them an interesting and suitable strategy for the treatment of chronic wounds.
Abstract: Nanoparticles have emerged as an important carrier system to treat wounds as they permit the topical administration of an antimicrobial drug in a sustained and effective manner. On the other hand, ...
TL;DR: Fujicalin-FDT-FU administration protected the stomach from oxidative damage and severe inflammatory response via the significant increase of glutathione level and the decreased levels of nitric oxide, interleukin and cyclooxygenase.
Abstract: Famotidine (FM) is considered among the first-line therapy for treatment of gastric ulcers; however, its poor aqueous solubility resulted in low bioavailability and limited therapeutic effi...
TL;DR: The results shown that that the highest release rates of CBD were obtained in SCF medium, with minor release in SGF and SIF media.
Abstract: In the current study a 3D-printable system was developed, based on natural, food-grade and nontoxic materials that may be used as a platform technology to host cannabinoids, and more specifically C...
TL;DR: Sol-Res showed improved in vitro passive permeation, in vitro cellular uptake, and in vivo corneal permeation over the free Res suspension solution, and the inhibition of key anti-inflammation mediators and the production of antioxidant factors in mRNA expression was observed in the Sol-Res treated wound healing corneas, suggesting that the mechanisms that regulate proinflammatory cytokines and oxidative stress might be involved in its therapeutic effect.
Abstract: Many eye diseases, such as corneal wound healing after injury, involve oxidative stress and inflammatory responses; however, many efficient natural antioxidants (e.g. resveratrol) have limited appl...
TL;DR: The protective effect of HPβCD, as measured by size exclusion chromatography, was most pronounced at C3′ and C3″, IgG:trehalose:HPβCD ratios of 1:2:0.05, which are superior to the previous examination with regards to manifesting lower aggregation and comparable FPF values.
Abstract: The great potential of hydroxypropyl beta-cyclodextrin (HPsCD), as a dried-protein stabilizer, has been attributed to various mechanisms namely water-replacement, vitrification and surfactant-like ...
TL;DR: The BUP dose in treatment of OUD should be individualized based on a continuous clinical benefit-risk assessment, as there is currently no consensus regarding optimal dose or dose-range of buprenorphine for treatment of opioid use disorder.
Abstract: Context: There is currently no consensus regarding optimal dose or dose-range of buprenorphine (BUP) for treatment of opioid use disorder (OUD).Objective: To elucidate the relationship betw...