C
Carine Darolles
Researcher at Institut de radioprotection et de sûreté nucléaire
Publications - 6
Citations - 221
Carine Darolles is an academic researcher from Institut de radioprotection et de sûreté nucléaire. The author has contributed to research in topics: Cobalt oxide & Cobalt. The author has an hindex of 5, co-authored 6 publications receiving 197 citations.
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Journal ArticleDOI
Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells
Richard Ortega,Carole Bresson,Carine Darolles,Céline Gautier,Stéphane Roudeau,Laura Perrin,Myriam Janin,Magali Floriani,Valérie Aloin,Asuncion Carmona,Véronique Malard +10 more
TL;DR: Cobalt oxide particles are readily internalized by pulmonary cells via the endo-lysosomal pathway and can lead, through a Trojan-horse mechanism, to intracellular release of toxic metal ions over long periods of time, involving specific toxicity.
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Different genotoxic profiles between depleted and enriched uranium
Carine Darolles,D. Broggio,A. Feugier,Sandrine Frelon,Isabelle Dublineau,M. De Meo,F. Petitot +6 more
TL;DR: It was showed that the genotoxic profile of uranium depends on its isotopic composition, and DU and EU are low and high clastogens, respectively, however, DU aneugenic effects remain high.
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Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zinc
Carole Bresson,Carine Darolles,Asuncion Carmona,Céline Gautier,Nicole Sage,Stéphane Roudeau,Richard Ortega,Eric Ansoborlo,Véronique Malard +8 more
TL;DR: A clear synergistic increase in toxicity was observed as well as a substantial increase in zinc content within cells, highlighting the potential hazard to lung function, of combined exposure to cobalt and zinc.
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Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways.
Chiara Uboldi,Thierry Orsière,Carine Darolles,Valérie Aloin,Virginie Tassistro,Isabelle George,Véronique Malard +6 more
TL;DR: It is demonstrated that the genotoxic effects of Co3O4P are not simply due to the released Co2+ but are induced by the particles themselves, as genotoxicity is observed at very low Co3 O4P concentrations.
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In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference
TL;DR: It is shown that cobalt particles interfere with most of the in vitro toxicity tests, and the protocol of the CellTiter-Glo assay is adapted to circumvent this interference and it is demonstrated that the toxicity level is consistent with results obtained using the clonogenic assay.