Stéphane Roudeau

TL;DR: Cobalt oxide particles are readily internalized by pulmonary cells via the endo-lysosomal pathway and can lead, through a Trojan-horse mechanism, to intracellular release of toxic metal ions over long periods of time, involving specific toxicity.

TL;DR: It is demonstrated that S OD1 in the Parkinson’s disease brain exhibits evidence of misfolding and metal deficiency, similar to that seen in mutant SOD1 in fALS, and this shared restricted proteinopathy highlights the potential translation of therapeutic approaches targeting Sod1 toxicity into disease-modifying treatments for Parkinson's disease.

TL;DR: Results indicate that the Golgi apparatus plays an important role in the cellular detoxification of manganese, and induces a decrease in total iron content, which could contribute to the overall neurotoxicity.

TL;DR: It is shown that, in neurons exposed to excess iron, the mere over-expression of human α-synuclein results in increased levels of intracellular iron and in iron redistribution from the cytoplasm to the perinuclear region within α- synuclein-rich inclusions.

TL;DR: The results suggest that the optimal sample preparation method to study elemental distribution in single whole cells prepared for X-ray microanalysis is achieved when cells are rinsed with ammonium acetate, quickly frozen by plunging into liquid nitrogen–chilled cryogenic fluid and freeze-dried at low temperatures.