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Carl-Fredrik Burman

Researcher at AstraZeneca

Publications -  40
Citations -  814

Carl-Fredrik Burman is an academic researcher from AstraZeneca. The author has contributed to research in topics: Population & Hazard ratio. The author has an hindex of 15, co-authored 36 publications receiving 682 citations. Previous affiliations of Carl-Fredrik Burman include Chalmers University of Technology.

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A recycling framework for the construction of Bonferroni-based multiple tests.

TL;DR: Bonferroni-based multiple testing procedures (MTPs) are described as strategies to split and recycle test mass, and whenever a null hypothesis is rejected, the part of alpha allocated to it may be recycled to the testing of other hypotheses.
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Are flexible designs sound

TL;DR: It is concluded that flexible design in its most general form with the corresponding weighted test is not valid and several possible modifications of the flexible design methodology are discussed with a focus on alternative hypothesis tests.
Journal ArticleDOI

Nonproportional Hazards for Time-to-Event Outcomes in Clinical Trials: JACC Review Topic of the Week

TL;DR: This review presents real examples of cardiology trials with different types of non-PH: an early treatment effect, a late treatment effect), and a diminishing treatment effect; the relative merits of a Cox model, an accelerated failure time model, a milestone analysis, and restricted mean survival time are examined.