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Carl J. Bentzel
Researcher at East Carolina University
Publications - 29
Citations - 2555
Carl J. Bentzel is an academic researcher from East Carolina University. The author has contributed to research in topics: Tight junction & Necturus. The author has an hindex of 18, co-authored 29 publications receiving 2474 citations. Previous affiliations of Carl J. Bentzel include Free University of Berlin & University at Buffalo.
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Journal ArticleDOI
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
H. Schmitz,Christian Barmeyer,Michael Fromm,Norbert Runkel,Hans-Dieter Foss,Carl J. Bentzel,Ernst-Otto Riecken,Jörg-Dieter Schulzke +7 more
TL;DR: The inflamed colonic mucosa in UC has an impaired barrier function that is much more pronounced than previously assumed and an altered TJ structure contributes to this barrier defect which, because of increased back leak, can reduce net ion transport.
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Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6.
H. Schmitz,Michael Fromm,Carl J. Bentzel,Peter Scholz,Katharina Detjen,Joachim Mankertz,Hagen Bode,Hans-Jörg Epple,Ernst-Otto Riecken,Jörg-Dieter Schulzke +9 more
TL;DR: TNFalpha impairs epithelial barrier function by altering structure and function of the tight junction, which could be of pathogenic relevance in intestinal inflammation.
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Regulation of epithelial tight junction permeability by cyclic AMP.
TL;DR: Freeze-fracture electron microscopy of tissues fixed with glutaraldehyde during the peak electrical response showed a reorientation of intramembranous junctional fibrils, suggesting that cyclic AMP reduces the ionic permeability of the paracellular pathway in this epithelium by altering the structure of tight junctions.
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Antagonism of the effects of furosemide by in domethacin in normal and hypertensive man
TL;DR: The results are compatible with hypothesis that the antihypertensive and natriuretic effects of furosemide might be mediated at least in part by prostaglandin synthesis and should be considered when using this drug in hypertensive patients and in subjects requiring diuretic therapy.
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Epithelial Tight Junction Structure in the Jejunum of Children with Acute and Treated Celiac Sprue
Jörg-Dieter Schulzke,Carl J. Bentzel,Ines Schulzke,Ines Schulzke,Ernst-Otto Riecken,Michael Fromm +5 more
TL;DR: It is concluded that the epithelial barrier function of the small intestine is seriously disturbed by structural modifications of the tight junction in acute symptomatic celiac disease, thereby accounting for increased ionic permeability noted in a parallel study on identical specimens.