Carl Sung

TL;DR: The ability of SWCNT to suppress mast cell pro-inflammatory function via a novel recognition mechanism is consistent with the ability of C-60 fullerenes to suppressive of mast cell-driven inflammatory responses.

TL;DR: Unbiased analysis of the impact of the presence of LB on the rate of trans-cytoplasmic calcium signals suggest that LB enrichment accelerates calcium propagation, which may reflect a Bernoulli effect.

TL;DR: It is described that immunologically stimulated LPMBs in mast cells are constrained to form in locations where dissociation of the membrane-associated cytoskeleton occurs, providing new insights into the physiological manifestations of LPMB in response to immunologically relevant stimuli and in the absence of cell stress, death or apoptotic pathways.

TL;DR: It is demonstrated that in vivo hyperinsulinemia resulting from high fat diet is associated with LB accumulation in murine mast cells and basophils, and lipidomic analysis suggests a gain of function associated withLB accumulation, in terms of elevated levels of eicosanoid precursors that translate to enhanced antigen-induced LTC4 release.

TL;DR: Comparing endocrine, pharmacological, and innate immunological stimuli for their ability to induce steatosis and phospholipidosis in a rat basophilic leukemia mast cell model concluded that lipotoxicity-inducing pathways in this model mast cell system are diverse, and include steatotic responses to an endocrine stimulus, as well as phospholIPidosis responses to cationic lipophilic drugs not previously described in this cell type.