Carlos Calvo

TL;DR: Results indicate that, in resistant hypertension, time of treatment may be more important for blood pressure control and for the proper modeling of the circadian blood pressure pattern than just changing the drug combination.

TL;DR: Bedtime dosing with nifedipine GITS is more effective than morning dosing, while also significantly reducing adverse effects, and valsartan administration at bedtime results in an improved diurnal/nocturnal BP ratio, increased percentage of controlled patients, and significant reduction in urinary albumin excretion in hypertensive patients.

TL;DR: In non-dipper hypertensive patients, dosing time with valsartan should be chosen at bedtime, for improved efficacy during the nocturnal resting hours, as well as the potential associated reduction in cardiovascular risk.

TL;DR: In patients with resistant hypertension, pharmacological therapy should take into account when to treat with respect to the rest–activity cycle of each patient to improve control and to avoid the non-dipper pattern associated to higher cardiovascular risk.

TL;DR: The lack of nocturnal decline in blood pressure has been associated with an increase in end-organ damage and cardiovascular events, although results remain controversial, partly because of the inability to reproduce correctly over time, the classification of patients into dippers and non.