Showing papers in "Advanced Drug Delivery Reviews in 2007"

TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.

TL;DR: Physicochemical principles of salt solubility are presented, with special reference to the influence of pH-solubility profiles of acidic and basic drugs on salt formation and dissolution.

TL;DR: The concept and theory of crystal engineering is covered and the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles are discussed.

TL;DR: A wide range of natural-origin polymers with special focus on proteins and polysaccharides that are being used in research, or might be potentially useful as carriers systems for active biomolecules or as cell carriers with application in the tissue engineering field targeting several biological tissues are overviewed.

TL;DR: This review will discuss the three primary technologies available to create tissue engineering scaffolds that are capable of mimicking native tissue, as well as explore the wide array of materials investigated for use in scaffolds.

TL;DR: The principles behind nanosizing, the production and characterization of nanoformulations as well as the current experience with utilization of such formulations in vivo are described.

TL;DR: The materials, techniques and post modification methods to functionalize electrospun nanofibrous scaffolds suitable for biomedical applications are reviewed.

TL;DR: Current work is investigating a synthetic receptor approach for high affinity binding of targeted macromolecules to the endolysosomal pathway, which has serious potential for improving drug delivery for the treatment of lysosomal storage diseases, cancer, and Alzheimer's disease.

TL;DR: This review discusses mechanistic aspects of RNAi, the potential problem areas and solutions and therapeutic applications, and it is anticipated that RNAi will be a major therapeutic modality within the next several years.

TL;DR: Solid lipid particulate systems such as solid lipid nanoparticles (SLN), lipid microparticles (LM) and lipospheres) seem to fulfil the requirements for an optimum particulate carrier system for therapeutic peptides, proteins and antigens.

TL;DR: A list of growth factors implicated in repair and regeneration of bone and cartilage by addressing their biological effects at different stages of the healing process is described and general requirements for localized growth factor delivery carriers are discussed.

TL;DR: Work from in vitro permeation studies to clinical performance is reviewed, presenting various experimental models used in dermal/transdermal research, including the use of excised human or animal skin, cultured skin equivalents and animals.

TL;DR: The article gives an overview of the cosmetic benefits of lipid nanoparticles, that means enhancement of chemical stability of actives, film formation, controlled occlusion, skin hydration, enhanced skin bioavailability and physical stability of the lipid nanoparticle as topical formulations.

TL;DR: This review aims to outline injectable materials and processing techniques used in both tissue engineering and drug delivery and to describe methods by which current injectable material in the field of drug delivery can be adapted for use as injectable scaffolds for tissue engineering.

TL;DR: Electrostatic fiber formation, also known as "electrospinning", has emerged in recent years as the popular choice for producing continuous threads, fiber arrays and nonwoven fabrics with fiber diameters below 1 microm for a wide range of materials.

TL;DR: The dermal uptake from SLN and NLC to the one of alternative vehicle systems is compared and a special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration.

TL;DR: This review explores the use of pro drug interventions to effect improved oral and parenteral delivery of poorly water-soluble problematic drugs, using both marketed as well as investigational prodrugs as examples.

TL;DR: This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives.

TL;DR: The prospect of improved cancer chemotherapy using solid lipid nanoparticles (SLN) as a drug delivery system is promising and it is anticipated that, in the near future, SLN will be further improved to deliver anticancer compounds in a more efficient, specific and safer manner.

TL;DR: The high density and slow biodegradability of ceramics is not beneficial for tissue engineering purposes, so macroporosity can be introduced often in combination with osteoinductive growth factors and cells to address these issues.

TL;DR: A brief overview of selected mouse models of IBD are provided and their contribution to the current understanding of disease mechanisms that contribute to IBD is discussed.

TL;DR: The present review discusses the various aspects of the studies and emphasizes the need for understanding of the molecular mechanisms of intracellular trafficking of nanoparticles in order to develop an efficient cytosolic delivery system.

TL;DR: Synthetic polymers that have been used for tissue growth scaffold fabrication and their applications in both cell and extracellular matrix support and controlling the release of cell growth and differentiation supporting drugs are reviewed.

TL;DR: The development of polyoxazoline-based polymers in biological and biomedical application contexts since the beginning of the millennium is reviewed, including nanoscalar systems such as membranes and nanoparticles, drug and gene delivery applications, as well as stimuli-responsive systems.

TL;DR: This article concentrates on the successes in this new millennium in developing potential non-invasive technologies and devices, and on major new milestones in modern insulin delivery for the effective treatment of diabetes.

TL;DR: The initial findings for multipotent stem cells and also the elasticity-coupled effects of drugs on cancer cells and smooth muscle cells are summarized and the differential effects not only lend insight into mechano-sensing of the substrate by cells, but also have important implications for regeneration and molecular therapies.

TL;DR: The current status of surface engineered and drug releasing scaffolds for tissue engineering, which can be designed to release bioactive molecules in a sustained manner to facilitate tissue regeneration, is reviewed.

TL;DR: The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes and the state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices.

TL;DR: Suggestions for future directions of research in the field of neural tissue engineering are presented based on the current body of work and common methods of drug delivery, including degradable/diffusion-based delivery systems, affinity-based Delivery Systems, and electrically controlled drug delivery systems are presented.

TL;DR: To illustrate the enormous progress that has been achieved in the important field of controlled release, some of the recently developed cell carriers with controlled release capacity, including both solid scaffolds and hydrogel-derived scaffolds are described and possible solutions for unresolved issues are illustrated.