Zinc supplementation improves glycemic control for diabetes prevention and management: a systematic review and meta-analysis of randomized controlled trials.

Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc intake, as well as serum/plasma and whole blood zinc concentration, and risk of T2DM. Observational studies, conducted on cases of incident diabetes or T2DM patients and healthy subjects that reported a measure of association between zinc exposure and T2DM, were selected. Random effects meta-analyses were applied to obtain combined results. Stratified meta-analyses and meta-regressions were executed to assess sources of heterogeneity, as well as the impact of covariates on the findings. From 12,136 publications, 16 studies were selected. The odds ratio (OR) for T2DM comparing the highest versus lowest zinc intake from diet was 0.87 (95% CI: 0.78–0.98). Nevertheless, no association between supplementary or total zinc intake from both diet and supplementation, and T2DM was observed. A direct relationship was found between serum/plasma zinc levels and T2DM (OR = 1.64, 95% CI: 1.25–2.14). A moderately high dietary zinc intake, in relation to the Dietary Reference Intake, could reduce by 13% the risk of T2DM, and up to 41% in rural areas. Conversely, elevated serum/plasma zinc concentration was associated with an increased risk of T2DM by 64%, suggesting disturbances in zinc homeostasis.

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Effects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-Analysis.

A facile ultrasonic-aided biosynthesis of ZnO nanoparticles using Vaccinium arctostaphylos L. leaf extract and its antidiabetic, antibacterial, and oxidative activity evaluation.

This editorial aims to examine the risk factors associated with type 2 diabetes and to discuss the evidence relating to dietary strategies for managing people with this condition. It is clear from the evidence presented that a range of dietary interventions can provide useful approaches for managing people with type 2 diabetes, including the regulation of blood glucose and lipid parameters, and for reducing the risks of acute and chronic diabetic complications.

https://www.mdpi.com/2072-6643/11/9/2177/pdf

Dietary Intake and Type 2 Diabetes.

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression.

Role of ethnicity and environment on lifestyle and cardiometabolic profile in the Native American Mapuche population: Protocol for a systematic review and meta-analysis.

The aim of this study was to compare the insulin resistance and the glucose and insulin concentration between subjects of Mapuche ethnicity and descendants of Europeans. Study registered in Prospero (CRD42017069924). The search was carried out in Pubmed/Medline, Scopus, Web of Science and Scielo until June 16, 2017. Observational studies conducted on adult subjects, of both sexes, of Mapuche ethnicity and descendants of Europeans residents in Chile, who presented data on the mean and standard deviation of insulin resistance, glucose and insulin were included. The first selection of studies was carried out from the title and the abstract. All potential relevant manuscripts were examined in full to determine if they finally met the selection criteria. Data were expressed as mean differences, and they were calculated as the difference between the values of glucose, insulin and insulin resistance in subjects of Mapuche ethnicity and descendants of Europeans. The global mean difference (GMD) and the 95 % confidence interval (CI) were calculated using the generic inverse variance method with random effects models. Stratified analyses were carried out to examine the influence of the area of residence, rural or urban. The Cochran test and the I statistic were used to study the heterogeneity between the studies. The publication bias was evaluated using the Begg tests. All analyzes were performed using STATA 15·0. 2314 manuscripts were identified, of which four were selected (1–4). Through stratified analysis, significant differences between subjects of Mapuche ethnicity and descendants of Europeans, were found in insulin levels and insulin resistance in rural areas, 3·28ρmol/L (95 % CI: 1·69, 4·87) and 0·81 (95 % CI: 0·43, 1·19), respectively. These differences were even more evident in urban areas, 14·97ρmol/L (95 % CI: 12·20, 17·74), for insulin and 3·41 (95 % CI: 2·52, 4·30) for insulin resistance (Figure 1). Heterogeneity was low or undetectable in all sub-analyses, and no evidence of publication bias was found in any meta-analyses.

Carlos Doepking

Papers

Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression.

Role of ethnicity and environment on lifestyle and cardiometabolic profile in the Native American Mapuche population: Protocol for a systematic review and meta-analysis.

Glucose metabolism in subjects of Mapuche ethnicity and descendants of Europeans: A systematic review and meta-analysis

[Emotional eating during COVID-19 lockdown].