C
Carmen O.N. Leung
Researcher at University of Hong Kong
Publications - 9
Citations - 465
Carmen O.N. Leung is an academic researcher from University of Hong Kong. The author has contributed to research in topics: microRNA & Notch signaling pathway. The author has an hindex of 7, co-authored 9 publications receiving 424 citations.
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Journal ArticleDOI
MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells.
Ronald T.K. Pang,Carmen O.N. Leung,Tian-Min Ye,Weimin Liu,Philip C.N. Chiu,Kevin K.W. Lam,Kai-Fai Lee,William S.B. Yeung +7 more
TL;DR: Evidence is provided that miR-34a inhibits invasiveness through regulation of the Notch pathway and its downstream matrix degrading enzyme.
Journal ArticleDOI
miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway
Carmen O.N. Leung,Wen Deng,Tian-Min Ye,Hextan Y.S. Ngan,Sai Wah Tsao,Annie N.Y. Cheung,Ronald T.K. Pang,William S.B. Yeung +7 more
TL;DR: It is demonstrated that HPV E6/E7 proteins are prerequisite for miR-135a as an oncomiR and SIAH1/β-catenin signaling is important in the transformation and progression of cervical carcinoma.
Journal ArticleDOI
Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Kevin K.W. Lam,Philip C.N. Chiu,Cheuk-Lun Lee,Ronald T.K. Pang,Carmen O.N. Leung,Hannu Koistinen,Markku Seppälä,Pak Chung Ho,William S.B. Yeung +8 more
TL;DR: Results show that GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway.
Journal ArticleDOI
MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1
Ronald T K Pang,Carmen O.N. Leung,Cheuk-Lun Lee,Kevin Kw Lam,Tian-Min Ye,Philip C. N Chiu,William Sb Yeung +6 more
TL;DR: Transient miR-34a force-expression significantly suppressed cell proliferation and invasion in BeWo and JEG-3 cells, at least, partially through its inhibitory effect on DLL1.
Journal ArticleDOI
miR-135A Regulates Preimplantation Embryo Development through Down-Regulation of E3 Ubiquitin Ligase Seven in Absentia Homolog 1A (SIAH1A) Expression
Ronald T.K. Pang,Weimin Liu,Carmen O.N. Leung,Tian-Min Ye,Peter C. K. Kwan,Kai-Fai Lee,William S.B. Yeung +6 more
TL;DR: It is demonstrated for the first time that zygotic specific miRNA modulates the first cell cleavage through regulating expression of Siah1a in preimplantation embryos.