C
Carol MacKintosh
Researcher at University of Dundee
Publications - 103
Citations - 10656
Carol MacKintosh is an academic researcher from University of Dundee. The author has contributed to research in topics: Phosphorylation & Phosphatase. The author has an hindex of 49, co-authored 100 publications receiving 9960 citations. Previous affiliations of Carol MacKintosh include Medical Research Council & University of Glasgow.
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Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.
TL;DR: The cyclic heptapeptide, microcystin‐LR, inhibits protein phosphatases 1 (PP1) and 2A (PP2A) with K i, values below 0.1 nM, and this results are strikingly similar to those obtained with the tumour promoter okadaic acid.
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Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.
Jun O. Liu,Mark W. Albers,Thomas J. Wandless,Sheng Luan,D. G. Alberg,Peter J. Belshaw,Philip Cohen,Carol MacKintosh,C. B. Klee,Stuart L. Schreiber +9 more
TL;DR: A strong correlation is demonstrated between the ability of these analogues, when bound to their immunophilins, to inhibit the phosphatase activity of calcineurin and their ability to inhibit transcriptional activation by NF-AT, a T cell specific transcription factor that regulates IL-2 gene synthesis in human T cells.
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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.
TL;DR: This work indicates that the cellular complement of 14-3-3 proteins may integrate the specificity and strength of signalling through to different cellular responses, and linking specific 14- 3-3 isoforms to genetic disorders and cancers, and the cellular effects of 13.3-2 agonists and antagonists, indicate that this role is important.
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14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.
Mercedes Pozuelo Rubio,Kathryn M. Geraghty,Barry Hon Cheung Wong,Nicola T. Wood,David G. Campbell,Nick Morrice,Carol MacKintosh +6 more
TL;DR: The findings suggest that 14-3-3s may be central to integrating the regulation of biosynthetic metabolism, cell proliferation, survival, and other processes in human cells.
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Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
Carina I. Holmberg,Ville Hietakangas,Andrey Mikhailov,Jouni O. Rantanen,Marko J. Kallio,Annika Meinander,Jukka Hellman,Nick Morrice,Carol MacKintosh,Richard I. Morimoto,John E. Eriksson,John E. Eriksson,Lea Sistonen +12 more
TL;DR: This study provides the first evidence that phosphorylation is essential for the transcriptional activity of HSF1, and hence for induction of the heat shock response.