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Carola Ponzetto
Researcher at University of Turin
Publications - 70
Citations - 7222
Carola Ponzetto is an academic researcher from University of Turin. The author has contributed to research in topics: Receptor tyrosine kinase & Hepatocyte growth factor. The author has an hindex of 38, co-authored 69 publications receiving 7024 citations. Previous affiliations of Carola Ponzetto include New York University.
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Journal ArticleDOI
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
Carola Ponzetto,Alberto Bardelli,Alberto Bardelli,Z Zhen,Flavio Maina,Paolo dalla Zonca,Silvia Giordano,Andrea Graziani,George Panayotou,Paolo M. Comoglio +9 more
TL;DR: The existence in the hepatocyte growth factor/scatter factor (HGF/SF) receptor of a multifunctional docking site made of the tandemly arranged degenerate sequence YVH/NV is reported, suggesting that in all members of the HGF/ SF receptor family, signal transduction is channeled through a multifunctionsal binding site.
Journal ArticleDOI
Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.
Luigi Naldini,K.M. Weidner,Elisa Vigna,Giovanni Gaudino,Alberto Bardelli,Carola Ponzetto,R. P. Narsimhan,Guido Hartmann,R. Zarnegar,George K. Michalopoulos +9 more
TL;DR: It is concluded that the same molecule (SF/HGF), purified according to their respective biological activities, acts as a growth or motility factor through a single receptor in different target cells.
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Tyrosine kinase receptor indistinguishable from the c-met protein.
TL;DR: It is shown that p190 is indistinguishable from the protein encoded by the c-met protooncogene and that the αβ-subunit structure is conserved in other human cell lines, and the high level of p190 found in the GTL-16 cell line is accompanied by amplification and overexpression of c- Met.
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HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.
Alberto Bardelli,Paola Longati,Daniela Albero,Sandro Goruppi,Claudio Schneider,Carola Ponzetto,Paolo M. Comoglio +6 more
TL;DR: The finding of a link between growth factor receptors and the anti‐apoptotic machinery fills a gap in the understanding of the molecular events regulating programmed cell death.
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Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Flavio Maina,Franca Casagranda,Enrica Audero,Antonio Simeone,Paolo M. Comoglio,Rüdiger Klein,Carola Ponzetto +6 more
TL;DR: The data show that the requirements for Met signaling vary depending on the tissue and reveal a novel role for HGF/ Met in late myogenesis, as well as highlighting the importance of knowing the carrier and removal status of canine coronavirus.