Signaling Recognition Events with Fluorescent Sensors and Switches.

Anion recognition chemistry has grown from its beginnings in the late 1960s with positively charged ammonium cryptand receptors for halide binding to, at the end of the millennium, a plethora of charged and neutral, cyclic and acyclic, inorganic and organic supramolecular host systems for the selective complexation, detection, and separation of anionic guest species. Solvation effects and pH values have been shown to play crucial roles in the overall anion recognition process. More recent developments include exciting advances in anion-templated syntheses and directed self-assembly, ion-pair recognition, and the function of anions in supramolecular catalysis.

Anion Recognition and Sensing: The State of the Art and Future Perspectives

Fluorogenic and chromogenic chemosensors and reagents for anions.

Crown ethers: sensors for ions and molecular scaffolds for materials and biological models.

Luminescent sensors and switches in the early 21st century

Fluorescent signalling of the brain neurotransmitter γ-aminobutyric acid and related amino acid zwitterions

Background:
Vascular dementia (VaD) is the most common cause of dementia in the elderly, second only to Alzheimer’s disease (AD). Between 1% and 4% of people of 65 years of age suffer from VaD and the prevalence appears to double every 5–10 years after the age of 65.

Catherine McVeigh

Papers

Fluorescent signalling of the brain neurotransmitter γ-aminobutyric acid and related amino acid zwitterions

Vascular dementia: prevention and treatment.

Fluorescent Signalling of the Brain Neurotransmitter γ- Aminobutyric Acid and Related Amino Acid Zwitterions.