Celia Casas

TL;DR: The data demonstrate that the production of ROS by AMB is a universal and important action mechanism that is correlated with the fungicidal effect and might explain the low rate of resistance to the molecule.

TL;DR: The results indicate that in C. neoformans, Amphotericin B causes intracellular damage mediated through the production of free radicals before damage on the cell membrane, measured by propidium iodide uptake.

TL;DR: It is demonstrated that AFT1 protein is required for maintaining detectable non‐induced levels of FET3 expression and for induction of FRE2 in iron starvation conditions, and it might link induction of genes for iron uptake to other metabolically dominant requirements for cell growth.

TL;DR: Results underline the functional conservation of Grx5 homologues throughout evolution and compartmentalize the Escherichia coli and Synechocystis sp.

TL;DR: Both Grx6 and Grx7 have measurable oxidoreductase activity in vivo, which is increased in the presence of tunicamycin, which could be responsible for the regulation of the sulfhydryl oxidative state at the oxidant conditions of the early secretory pathway vesicles.