C
Cenk Kig
Researcher at Katholieke Universiteit Leuven
Publications - 5
Citations - 272
Cenk Kig is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Maternal embryonic leucine zipper kinase & Kinase. The author has an hindex of 3, co-authored 4 publications receiving 239 citations.
Papers
More filters
Journal ArticleDOI
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.
Kaushal Joshi,Yeshavanth Kumar Banasavadi-Siddegowda,Xiaokui Mo,Sung Hak Kim,Ping Mao,Cenk Kig,Diana Nardini,Robert W. Sobol,Lionel M.L. Chow,Harley I. Kornblum,Ronald R. Waclaw,Monique Beullens,Ichiro Nakano +12 more
TL;DR: The data indicate that FOXM1 signaling through its direct interaction with MELK regulates key mitotic genes in GSCs in a PLK1‐dependent manner and thus, this protein complex is a potential therapeutic target for GBM.
Journal ArticleDOI
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.
Lijs Beke,Cenk Kig,Joannes T. M. Linders,Shannah Boens,An Boeckx,Erika van Heerde,Marc Parade,An De Bondt,Ilse Van den Wyngaert,Tarig Bashir,Souichi Ogata,Lieven Meerpoel,Aleyde Van Eynde,Christopher N. Johnson,Monique Beullens,Dirk Brehmer,Mathieu Bollen +16 more
TL;DR: It is shown that a novel M ELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence phenotype.
Journal ArticleDOI
Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells
Cenk Kig,Monique Beullens,Lijs Beke,Aleyde Van Eynde,Johannes T. Linders,Dirk Brehmer,Mathieu Bollen +6 more
TL;DR: It is shown that the siRNA-mediated loss of MELK in U87 MG glioblastoma cells causes a G1/S phase cell cycle arrest accompanied by cell death or a senescence-like phenotype that can be rescued by the expression of si RNA-resistant M ELK.