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Diana Nardini
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 12
Citations - 341
Diana Nardini is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Cerebrum & Subventricular zone. The author has an hindex of 7, co-authored 11 publications receiving 254 citations. Previous affiliations of Diana Nardini include University of Cincinnati.
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Journal ArticleDOI
MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.
Kaushal Joshi,Yeshavanth Kumar Banasavadi-Siddegowda,Xiaokui Mo,Sung Hak Kim,Ping Mao,Cenk Kig,Diana Nardini,Robert W. Sobol,Lionel M.L. Chow,Harley I. Kornblum,Ronald R. Waclaw,Monique Beullens,Ichiro Nakano +12 more
TL;DR: The data indicate that FOXM1 signaling through its direct interaction with MELK regulates key mitotic genes in GSCs in a PLK1‐dependent manner and thus, this protein complex is a potential therapeutic target for GBM.
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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival.
Ranjithmenon Muraleedharan,Mruniya V. Gawali,Deepak Tiwari,Abitha Sukumaran,Nicole Oatman,Jane Anderson,Diana Nardini,Mohammad Alfrad Nobel Bhuiyan,Ivan Tkáč,Amber L. Ward,Mondira Kundu,Ronald R. Waclaw,Ronald R. Waclaw,Lionel M L Chow,Christina Gross,Christina Gross,Raghavendra Rao,Stefanie Schirmeier,Biplab Dasgupta,Biplab Dasgupta +19 more
TL;DR: It is shown that the energy sensor AMP activated protein kinase (AMPK) regulates neuronal survival in a non-cell-autonomous manner and enables expression and surface translocation of the glucose transporter GLUT1, glucose uptake, and lactate production.
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The Protein Tyrosine Phosphatase Shp2 Is Required for the Generation of Oligodendrocyte Progenitor Cells and Myelination in the Mouse Telencephalon
Lisa A. Ehrman,Diana Nardini,Sarah Ehrman,Tilat A. Rizvi,James Gulick,Maike Krenz,Biplab Dasgupta,Jeffrey Robbins,Nancy Ratner,Masato Nakafuku,Ronald R. Waclaw +10 more
TL;DR: The notion that appropriate Shp2 activity levels control the number as well as the differentiation of oligodendrocytes during development is supported, as expression of this mutation negatively influenced myelination as mice displayed abnormal myelinated axons in the white matter despite elevated OPC numbers.
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Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence.
Heather Chapman,Amy N. Riesenberg,Lisa A. Ehrman,Vikram Kohli,Diana Nardini,Masato Nakafuku,Kenneth Campbell,Ronald R. Waclaw +7 more
TL;DR: It is found that Gsx1/2 double mutant embryos exhibit a more robust expansion of Olig2+ cells (i.e. OPCs) in the subventricular zone (SVZ) of the dLGE than Gs x2 mutants, and ectopic production of cortical O PCs observed in GsX2 mutants disappeared in Olig 2/Gsx2 double mutants.
Journal ArticleDOI
Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon.
Ronald R. Waclaw,Lisa A. Ehrman,Paloma Merchan-Sala,Vikram Kohli,Diana Nardini,Kenneth Campbell +5 more
TL;DR: Foxo1 is enriched in embryonic direct pathway striatal projection neurons (dSPNs) and Isl1 is upstream of Foxo family members Foxo1/3/6 in dSPNs, suggesting that Foxo‐regulated pathways are downstream of Isl 1 in the survival and/or differentiation of direct pathway SPNs.