Chad E. Stephens

TL;DR: In this article, a modified synthesis of tellurophene by reaction of diacetylene with sodium telluride is described, the primary modification involves the convenient in situ generation of sodium tellsuride by reduction of tellurium metal with NaBH 4 in water.

TL;DR: In vivo studies in N. caninum (Nc-1 isolate) infected mice showed that daily intraperitoneal application of DB745 for a period of 14 days resulted in a decreased number of clinically affected animals, and lower cerebral parasite burdens in DB745- treated mice compared to non-treated mice, illustrating the potential of dicationic arylimidamides for the treatment of N.caninum infections.

TL;DR: The data suggest that DB750 exerted its activity also after crossing the blood-brain barrier, and that this class of compounds could be promising for the control of N. caninum-associated disease.

TL;DR: Of the drugs investigated here, the diguanidino compound DB1127 represents the most promising compound for further study in appropriate in vivo models for Echinococcus multilocularis infection.

TL;DR: The astonishing capacity of T. gondii tachyzoites to adapt to environmental changes, at least under in vitro conditions, suggests that DB745 could be an interesting drug candidate for further assessments in appropriate in vivo models.