D
David W. Boykin
Researcher at Georgia State University
Publications - 406
Citations - 10965
David W. Boykin is an academic researcher from Georgia State University. The author has contributed to research in topics: DNA & Aryl. The author has an hindex of 54, co-authored 397 publications receiving 10212 citations. Previous affiliations of David W. Boykin include King Faisal University.
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Human African trypanosomiasis: pharmacological re-engagement with a neglected disease
TL;DR: The challenges of chemotherapy for human African trypanosomiasis (HAT) are discussed, and the few drugs registered for use against the disease are unsatisfactory for a number of reasons.
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Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents
Maurizio Del Poeta,Wiley A. Schell,Christine C. Dykstra,Susan Jones,Richard R. Tidwell,Agnieszka Czarny,Miroslav Bajić,Marina Bajic,Arvind Kumar,David W. Boykin,John R. Perfect +10 more
TL;DR: It is clear from the data presented here that further studies on the structure-activity relationships, mechanisms of action and toxicities, and in vivo efficacies of these compounds are warranted to determine their clinical potential.
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Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species.
TL;DR: New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids, and cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values similar to that of fluconazole.
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Antiparasitic compounds that target DNA.
W. David Wilson,Farial A. Tanious,Amanda Mathis,Denise Tevis,James Edwin Hall,David W. Boykin +5 more
TL;DR: Synthetic heterocyclic diamidines have excellent activity against eukaryotic parasites that cause diseases such as sleeping sickness and leishmania and adversely affect millions of people each year.
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Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge.
Elizabeth W. White,Farial A. Tanious,Mohamed A. Ismail,Anthony P. Reszka,Stephen Neidle,David W. Boykin,W. David Wilson +6 more
TL;DR: In this paper, the authors used surface plasmon resonance and isothermal titration calorimetry to show that binding affinity and selectivity of a series of quadruplex end-stacking molecules to human telomeric DNA are sensitive to compound shape as well as substituent type and position.