C
Chaitali Ghosh
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 40
Citations - 2100
Chaitali Ghosh is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Epilepsy & Blood–brain barrier. The author has an hindex of 20, co-authored 34 publications receiving 1670 citations. Previous affiliations of Chaitali Ghosh include Cleveland Clinic Lerner College of Medicine & Northeast Ohio Medical University.
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Journal ArticleDOI
Antagonism of peripheral inflammation reduces the severity of status epilepticus
Nicola Marchi,Q. Fan,Chaitali Ghosh,Vincent Fazio,Francesca Bertolini,Giulia Betto,Ayush Batra,Erin Carlton,Imad Najm,Tiziana Granata,Damir Janigro +10 more
TL;DR: The hypothesis that intravenous administration of IL-1 receptor antagonists (IL-1ra) may prevent pilocarpine-induced seizures is tested and the concept of targeting systemic inflammation and BBB for the prevention of status epilepticus is supported.
Journal ArticleDOI
Consequences of Repeated Blood-Brain Barrier Disruption in Football Players
Nicola Marchi,Jeffrey J. Bazarian,Vikram Puvenna,Mattia Janigro,Chaitali Ghosh,Jianhui Zhong,Tong Zhu,Eric G. Blackman,Desiree Stewart,Jasmina Ellis,Jasmina Ellis,Robert S. Butler,Damir Janigro +12 more
TL;DR: The correlation of serum S100B, auto-antibodies and DTI changes support a link between repeated BBBD and future risk for cognitive changes and predicted persistence of MRI-DTI abnormalities which in turn correlated with cognitive changes.
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Blood–brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches
TL;DR: A BBB‐centric view of seizure disorders is offered, linking several aspects of seizures and epilepsy physiopathology to BBB dysfunction, and the therapeutic, antiseizure effect of drugs that promote BBB repair is reviewed.
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Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy.
Vikram Puvenna,Madeline Engeler,Manoj Banjara,Chanda Brennan,Peter Schreiber,Aaron Dadas,Ashkon Bahrami,Jesal Solanki,Anasua Bandyopadhyay,Jacqueline K. Morris,Charles Bernick,Chaitali Ghosh,Edward Rapp,Jeffrey J. Bazarian,Damir Janigro +14 more
TL;DR: PT was quantified in TLE and CTE to unveil whether a history of rTBI is a prerequisite for PT accumulation in the brain, and showed that CTE had the most high molecular weight tangle-associated tau, whereas epileptic brain contained low molecularWeight tau.
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COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Relevance.
Aneesha Achar,Chaitali Ghosh +1 more
TL;DR: It is hypothesized that SARS-CoV-2 neuroinvasion, neuroinflammation, and blood-brain barrier (BBB) dysfunction may be implicated in the development of the observed disorders; however, further research is critical to understand the detailed mechanisms and pathway of infectivity behind CNS pathogenesis.