Chan Sun Park

TL;DR: Insight is provided into the beneficial role of metformin as a novel therapeutic drug for chronic asthma by reducing both airway inflammation and remodeling at least partially through the induction of AMPK activation and decreased oxidative stress.

TL;DR: In this paper, the authors demonstrated that the allergen-induced CD11b(+) CD11c(int) macrophage expressing CC chemokine receptor 3 (CCR3) in the lung performs a crucial function in the induction of eosinophilic asthma in a murine model.

TL;DR: Investigation of the sequential kinetics of oxidative stress in the lung, the development of airway inflammation, mucin hypersecretion, and airway hyperresponsiveness in an ovalbumin-sensitized and challenged mouse with and without antioxidant indicates that increased oxidative stressed precedes other pivotal phenotypes of allergic airway disease.

TL;DR: Previous exacerbation, duration of disease, and decrease in lung function were important clinical indices associated with asthma severity in the COREA study patients.

TL;DR: This study was conducted to evaluate the effectiveness of a computerized surveillance system for adverse drug events (ADEs) reinforced with mandatory reporting of all past drug hypersensitivity reactions and supervision of the processes by allergy specialists in a university hospital.