Journal ArticleDOI
Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase.
Chan Sun Park,Bo-Ram Bang,Hyouk-Soo Kwon,Keun-Ai Moon,Tae-Bum Kim,Ki-Young Lee,Hee-Bom Moon,You Sook Cho +7 more
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TLDR
Insight is provided into the beneficial role of metformin as a novel therapeutic drug for chronic asthma by reducing both airway inflammation and remodeling at least partially through the induction of AMPK activation and decreased oxidative stress.About:
This article is published in Biochemical Pharmacology.The article was published on 2012-12-15. It has received 163 citations till now. The article focuses on the topics: AMPK & Metformin.read more
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Metformin—mode of action and clinical implications for diabetes and cancer
Ida Pernicova,Márta Korbonits +1 more
TL;DR: The updated understanding of the antigluconeogenic action of met formin in the liver and the implications of the discoveries of metformin targets for the treatment of diabetes mellitus and cancer are discussed.
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The Warburg effect then and now: from cancer to inflammatory diseases.
TL;DR: The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies.
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Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect.
TL;DR: The basic and clinical evidence of the anti-inflammatory action of metformin is summarized and its clinical implication is discussed.
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Metformin reverses established lung fibrosis in a bleomycin model.
Sunad Rangarajan,Nathaniel B. Bone,Anna A. Zmijewska,Shaoning Jiang,Dae Won Park,Dae Won Park,Karen Bernard,Morgan L. Locy,Saranya Ravi,Jessy S. Deshane,Roslyn B. Mannon,Edward Abraham,Victor M. Darley-Usmar,Victor J. Thannickal,Jaroslaw W. Zmijewski +14 more
TL;DR: It is demonstrated that in humans with idiopathic pulmonary fibrosis (IPF) and in an experimental mouse model of lung fibrosis, AMPK activity is lower in fibrotic regions associated with metabolically active and apoptosis-resistant myofibroblasts, and support a role for metformin (or other AMPK activators) to reverse established fibrosis by facilitating deactivation and apoptotic deactivation of myofibiablasts.
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Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance.
Seon-Yeong Lee,Seung Hoon Lee,Eun-Ji Yang,Eun-Kyung Kim,Jae-Kyung Kim,Dong-Yun Shin,Mi-La Cho +6 more
TL;DR: The results of this mouse model of inflammatory bowel disease support the strategy of using p-STAT3 inhibitors to treat IBD, and have increased the understanding of this chronic inflammatory disease.
References
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Journal ArticleDOI
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Reuben J. Shaw,Reuben J. Shaw,Katja A. Lamia,Debbie S. Vasquez,Seung Hoi Koo,Seung Hoi Koo,Nabeel Bardeesy,Ronald A. DePinho,Marc Montminy,Lewis C. Cantley +9 more
TL;DR: It is shown that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels, and TORC2 is a critical target of L KB1/AMPK signals in the regulation of gluconeogenesis.
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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek,Valerie A. Gerriets,Sarah R. Jacobs,Andrew N. Macintyre,Nancie J. MacIver,Emily F. Mason,Sarah A. Sullivan,Amanda G. Nichols,Jeffrey C. Rathmell +8 more
TL;DR: Teff and Treg were selectively increased in Glut1 transgenic mice and reliant on glucose metabolism, whereas Treg had activated AMP-activated protein kinase and were dependent on lipid oxidation.
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Airway Structural Alterations Selectively Associated with Severe Asthma
TL;DR: It is concluded that fibroblast accumulation and ASM hypertrophy in proximal airways are selective determinants of severe persistent asthma.
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Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression
Jamila Chakir,Joanne Shannon,Sophie Molet,Motonori Fukakusa,Jack A. Elias,Michel Laviolette,Louis-Philippe Boulet,Qutayba Hamid +7 more
TL;DR: The results confirm the association of increased levels of TGF-beta, IL-11,IL-17, and types I and III collagens with severe disease and suggest that the failure of cortico-steroids to decrease collagen deposition might be due to persistently elevated T GF-beta expression.
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Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype
TL;DR: A role of AMP-activated protein kinase (AMPK) as a potent counterregulator of inflammatory signaling pathways in macrophages is demonstrated and it is found that AMPK negatively regulated LPS-induced IκB-α degradation and positively regulated Akt activation, accompanied by inhibition of glycogen synthase kinase β and activation of CREB.