C
Chang-Gu Hyun
Researcher at Myongji University
Publications - 93
Citations - 1865
Chang-Gu Hyun is an academic researcher from Myongji University. The author has contributed to research in topics: MAPK/ERK pathway & Kinase. The author has an hindex of 25, co-authored 79 publications receiving 1635 citations.
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Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages.
TL;DR: D-limonene is an effective inhibitor of lipopolysaccharide (LPS)-induced NO and prostaglandin E(2) production in RAW 264.7 macrophages and may be considered a potential anti-inflammatory candidate, according to the results.
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Accumulation of S-Adenosyl-l-Methionine Enhances Production of Actinorhodin but Inhibits Sporulation in Streptomyces lividans TK23
Dongjin Kim,Jung-Hyun Huh,Young-Yell Yang,Choong-Min Kang,Inhyung Lee,Chang-Gu Hyun,Soon-Kwang Hong,Joo-Won Suh +7 more
TL;DR: The overexpression of the SAM-s gene in Streptomyces lividans TK23 inhibited sporulation and aerial mycelium formation but enhanced the production of actinorhodin in both agar plates and liquid media, concluding that the SAM plays important roles as an intracellular factor in both cellular differentiation and antibiotic production in StrePTomyces sp.
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Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts.
TL;DR: Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts is screened for and promising candidates for the further purification of bioactive compounds are considered.
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Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages
Weon-Jong Yoon,Young Min Ham,Sang Suk Kim,Byoung-Sam Yoo,Ji-Young Moon,Jong Seok Baik,Nam Ho Lee,Chang-Gu Hyun +7 more
TL;DR: It is suggested that S. micracanthum extracts may be considered potential anti-inflammatory candidates for topical application and performed MTT assays on human dermal fibroblast cells, as well as primary skin irritation tests, and did not induce any adverse reactions.
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Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants
TL;DR: The results suggest that medicinal plants possessing several biological activities may be potent inhibitors of the processes involved in pigmentation increases and aging.