A steel property optimization model based on the XGBoost algorithm and improved PSO

A survey of scheduling with parallel batch (p-batch) processing

Minimizing total energy cost and tardiness penalty for a scheduling-layout problem in a flexible job shop system: A comparison of four metaheuristic algorithms

Energy-efficient scheduling for a permutation flow shop with variable transportation time using an improved discrete whale swarm optimization

Multi-objective energy-aware batch scheduling using ant colony optimization algorithm

In the Industry 4.0 environment, an ideal smart factory should be intelligent, green, and humanized, and the logistics transportation from raw materials to final products in the factory should be completed by smart logistics. In order to address the problems of low efficiency, poor workstation service satisfaction, high distribution costs, and non-greening during the logistics distribution processes in discrete smart manufacturing workshops are required. A mathematical model of optimized multi-objective green logistics distribution paths in a smart manufacturing workshop has been constructed in this study, with low costs, high efficiency, and workstation service satisfaction taken into consideration. Then, this mathematical model was solved with an improved ant colony optimization algorithm. A “time window span” was introduced in the basic ant colony optimization algorithm to prioritize the services to workstations with a relatively high urgency in material demand, with the aim of improving workstation service satisfaction. Lastly, in order to verify the effectiveness of the model and algorithm proposed in this study, a simulation experiment has been conducted on the workstation logistics distribution system in a smart manufacturing workshop to provide convincing evidence for optimizing workstation logistics distribution paths in workshops of discrete manufacturing enterprises.

Study on Multi-Objective Optimization of Logistics Distribution Paths in Smart Manufacturing Workshops Based on Time Tolerance and Low Carbon Emissions

Ulcerative colitis (UC) is a type of inflammatory bowel disease characterized by excessive and persistent inflammation. Intestinal macrophages play a considerable role in regulating inflammatory immune reactions in the gut mucosa. It has previously been reported that CD73 is related to the pathogenesis of inflammatory or immune-related diseases; however, the roles of CD73 in UC remain unclear. In this study, CD73 expression in the inﬂamed mucosa of patients with UC was examined using reverse transcription-quantitative PCR (RT-qPCR), western blotting, and immunohistochemistry. Adenosine 5'-(α, β-methylene) diphosphate (APCP) was used to block the expression of CD73. Furthermore, the mRNA levels of proinflammatory mediators associated with macrophages following the blocking of CD73 were examined using RT-qPCR. Finally, the regulatory function of CD73 in intestinal inflammation was assessed by administering APCP in a mouse model of dextran sulfate sodium salt (DSS)-induced colitis. Notably, it was found that CD73 expression was significantly increased in the colonic mucosal tissues of patients with UC. Blockade of CD73 inhibited the expression of pro-inflammatory cytokines but promoted the production of anti-inflammatory cytokines in macrophages, while its promotion of M2 macrophage polarization was also verified. In vivo, CD73 blockade markedly alleviated DSS-induced colitis in mice, as characterized by reduced weight loss, reduction in the incidence of diarrhea, and reduced amount of bloody stool. Mechanistically, it was shown that CD73 regulated macrophage differentiation via the NF-κB and ERK signaling pathways. In conclusion, the findings of the present study indicate that CD73 may have a potential impact on the pathogenesis of UC by modulating the immune response of macrophage differentiation; thus, providing a novel pathway for modulating mucosal inflammation in UC.

Chao Wu

Papers

Multi-objective energy-aware batch scheduling using ant colony optimization algorithm

Study on Multi-Objective Optimization of Logistics Distribution Paths in Smart Manufacturing Workshops Based on Time Tolerance and Low Carbon Emissions

CD73 blockade alleviates intestinal inflammatory responses by regulating macrophage differentiation in ulcerative colitis