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Charles E. deBock
Researcher at University of Newcastle
Publications - 1
Citations - 139
Charles E. deBock is an academic researcher from University of Newcastle. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 1, co-authored 1 publications receiving 132 citations.
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Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress
Chen Chen Jiang,K. M. Lucas,Kelly A. Avery-Kiejda,Margaret Wade,Charles E. deBock,Rick F. Thorne,John F. Allen,Peter Hersey,Xudong Zhang +8 more
TL;DR: The mechanisms of resistance of melanoma cells to apoptosis induction mediated by BH3-only proteins upon ER stress are revealed, and Mcl-1 is identified as a target for the treatment of melanomas in combination with therapeutics that induce ER stress.