Kelly A. Avery-Kiejda

TL;DR: The data reveal that coordinated hypermethylation can occur in oestrogen receptor-negative disease, and that characterizing the epigenetic framework provides a potential signature to stratify TNBCs, demonstrating the feasibility of profiling the cancer methylome with limited archival tissue to identify regulatory regions associated with cancer.

TL;DR: The mechanisms of resistance of melanoma cells to apoptosis induction mediated by BH3-only proteins upon ER stress are revealed, and Mcl-1 is identified as a target for the treatment of melanomas in combination with therapeutics that induce ER stress.

TL;DR: It is reported that p53β and Δ40p53 were expressed in the majority of melanoma cell lines at the mRNA level, but were absent or expressed at low levels in fibroblasts and melanocytes, suggesting that their expression may play a role in melanoma development.

TL;DR: This study supports recent observations that although rare, PALB2 mutations are present in a small but substantial proportion of inherited breast cancer cases, and indicates that RAD51C at a population level does not account for a substantial number of familial Breast cancer cases.

TL;DR: It is indicated that P53 target genes involved in apoptosis and cell cycle regulation are aberrantly expressed in melanoma and that this aberrant functional activity of P53 may contribute to the proliferation of melanoma.