Showing papers by "Charles H. Hennekens published in 1981"
TL;DR: The hypothesis that premature cessation of ovarian function increases the risk of nonfatal myocardial infarction is supported.
317 citations
TL;DR: Smokers experienced a three-fold increase in risk of MI relative to individuals who never smoked, which was not explained by history of hypertension, diabetes, high cholesterol or familial MI.
Abstract: The relationship between smoking and the risk of hospitalization for acute myocardial infarction (MI) was evaluated among 121,964 nurses and aged 30-55 years who resided in 11 of the larger US states and who responded to a mail questionnaire. Among 249 women who experienced an MI, 159 (64%) were smokers at the time of hospitalization. Of 4977 controls matched to the cases on the basis of age, 1850 (37%) were smoking at the corresponding time. Smokers experienced a three-fold increase in risk of MI relative to individuals who never smoked, which was not explained by history of hypertension, diabetes, high cholesterol or familial MI. Women who had stopped smoking experienced a risk of MI no greater than women who had never smoked.
40 citations
TL;DR: The presence of this relationship using non-hospitalized controls of similar social status to cases supports the reality of this association, which has recently been challenged as an artifact due to inappropriate choice of hospitalized controls.
Abstract: The relationship between age at birth of a first child and breast cancer was evaluated for 1159 affected women and 11,590 women without cancer in data collected in 1976 among married female registered nurses residing in 11 states in the United States. A positive trend of increasing risk of breast cancer with later ages at first birth was found (chi 2(1) for trend in proportions = 30.9, p less than 0.01). Adjustment for potential confounding variables by multiple logistic regression did not affect this trend. The presence of this relationship using non-hospitalized controls of similar social status to cases supports the reality of this association, which has recently been challenged as an artifact due to inappropriate choice of hospitalized controls.
35 citations
TL;DR: Smokers experienced a three-fold increase in risk of MI relative to individuals who never smoked, which was not explained by history of hypertension, diabetes, high cholesterol or familial MI.
Abstract: The relationship between smoking and the risk of hospitalization for acute myocardial infarction (MI) was evaluated among 121,964 nurses and aged 30-55 years who resided in 11 of the larger US states and who responded to a mail questionnaire. Among 249 women who experienced an MI, 159 (64%) were smokers at the time of hospitalization. Of 4977 controls matched to the cases on the basis of age, 1850 (37%) were smoking at the corresponding time. Smokers experienced a three-fold increase in risk of MI relative to individuals who never smoked, which was not explained by history of hypertension, diabetes, high cholesterol or familial MI. Women who had stopped smoking experienced a risk of MI no greater than women who had never smoked.
18 citations
TL;DR: Although the entire state of Florida has experienced an increase in lung cancer mortality during the present decade, a differential rise among white men has been observed in Duval, a county in its northeastern region, and an industrial exposure involving paper and pulp manufacturing, shipbuilding, or petroleum is hypothesized.
Abstract: Although the entire state of Florida has experienced an increase in lung cancer mortality during the present decade, a differential rise among white men has been observed in Duval, a county in its northeastern region. This increase is not explained by population changes or migration of cases. It is hypothesized that an industrial exposure involving paper and pulp manufacturing, shipbuilding, or petroleum may account for these findings.
3 citations
1 citations