Showing papers by "Charles H. Vite published in 2006"
TL;DR: It is demonstrated here that blood cells from these RV-treated MPS VII dogs had substantial copies of RV DNA, and expressed the RNA at 2% of the level found in liver, suggesting expression of GUSB in blood cells may synergize with uptake of G USB from blood to reduce storage in organs.
43 citations
TL;DR: Findings suggest that following dorsal rhinotomy and nasal polypectomy surgery, the dog developed herniation of the left olfactory bulb, intra-ventricular pneumocephalus, and septic meningo-encephalitis because of a cribriform plate defect.
Abstract: Case Description—A 4-year-old sexually intact female French Bulldog was evaluated because of lethargy, anorexia, and chronic rhinitis-sinusitis The dog had nasal discharge of 18 months' duration; dorsal rhinotomies were performed 3 months and 2 weeks prior to referral Clinical Findings—On initial evaluation, intraventricular pneumocephalus and sinusitis were diagnosed; CSF analysis revealed high total protein concentration and mononuclear pleocytosis The dog's condition improved with treatment Two weeks after discharge, it was treated by a local veterinarian because of upper airway obstruction; 3 days later, the dog was referred because of seizures Computed tomography revealed a large fluid-filled, left lateral ventricle and a soft tissue mass protruding through a cribriform plate defect The mass was histologically consistent with brain tissue Findings of clinicopathologic analyses were unremarkable Results of cytologic examination of a CSF sample were indicative of septic, suppurative inflammatio
28 citations