Showing papers by "Charles Huggins published in 1982"
TL;DR: The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain of Sprague-Dawley rats, where myelogenous leukemia was not produced.
Abstract: The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythro-leukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.
24 citations
TL;DR: Four erythroleukemia cell lines were established in vitro from rats with primary leukemias induced by a set of intravenous injections of 7,8,12-trimethylbenz[a] anthracene (TMBA), characterized by specific consistent chromosome abnormalities, related to No. 2 chromosome.