C
Charlotte Delay
Researcher at Janssen Pharmaceutica
Publications - 2
Citations - 26
Charlotte Delay is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Tauopathy & PIKFYVE. The author has an hindex of 2, co-authored 2 publications receiving 9 citations.
Papers
More filters
Journal ArticleDOI
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding.
Alberto Carpinteiro Soares,Alberto Carpinteiro Soares,Andreia Ferreira,Andreia Ferreira,Jonas Mariën,Charlotte Delay,Edward B. Lee,John Q. Trojanowski,Dieder Moechars,Wim Annaert,Louis De Muynck +10 more
TL;DR: In this article, the authors studied the role of different endosomal routes in the neuronal uptake of preformed tau seeds and identified dynamin-1, actin, and Rac1 as key players.
Journal ArticleDOI
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
Alex Crowe,Mark J. Henderson,Johnathon Anderson,Steve Titus,Alexey V. Zakharov,Anton Simeonov,Arjan Buist,Charlotte Delay,Diederik Moechars,John Q. Trojanowski,Virginia M.-Y. Lee,Kurt R. Brunden +11 more
TL;DR: It is suggested that neurons, the cells most affected by tau pathology in AD, are very suitable for screening for tau inclusion inhibitors, and the Prestwick library of mostly approved drugs in the cortical neuron assay led to the identification of a greater number of t Tau inclusion inhibitors.