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Edward B. Lee

Researcher at University of Pennsylvania

Publications -  218
Citations -  15188

Edward B. Lee is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Frontotemporal lobar degeneration & Medicine. The author has an hindex of 55, co-authored 185 publications receiving 10491 citations. Previous affiliations of Edward B. Lee include Children's Hospital of Philadelphia & National Institutes of Health.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

Johannes Brettschneider, +19 more
- 19 Jun 2013 - 
TL;DR: To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages, a chiral model is constructed.
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Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

Edward B. Lee, +2 more
- 01 Jan 2012 - 
TL;DR: Experimental studies are attempting to determine whether TDP43-mediated neurodegeneration results from a gain or a loss of function of the protein, and the distinct possibility of pleotropic or combined effects.
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Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

Manuela Neumann, +11 more
- 06 Jan 2009 - 
TL;DR: Novel rat monoclonal antibodies raised against phosphorylation of S409/410 of TDP-43 are developed and characterized and will be extremely useful for the neuropathological routine diagnostics of T DP-43 proteinopathies and for the investigation of emerging cellular and animal models for TSPs.
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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Erik C. B. Johnson, +33 more
- 13 Apr 2020 - 
TL;DR: Large-scale, comprehensive proteomic profiling of Alzheimer’s disease brain and cerebrospinal fluid reveals disease-associated protein coexpression modules and highlights the importance of glia and energy metabolism in disease pathogenesis.