Charlotte E. Hotchkiss

TL;DR: Ketamine increased N-methyl-D-aspartate (NMDA) receptor NR1 subunit messenger RNA in the frontal cortex where enhanced cell death was apparent and a shorter duration of ketamine anesthesia did not result in neuronal cell death in the 5-day-old monkey.

TL;DR: It is demonstrated that a single 24-h episode of ketamine anesthesia, occurring during a sensitive period of brain development, results in very long-lasting deficits in brain function in primates and provides proof-of-concept that general anesthesia during critical periods of brainDevelopment can result in subsequent functional deficits.

TL;DR: The data suggest that NR1 antisenses and SN-50 offer neuroprotection from the enhanced degeneration induced by ketamine in vitro, and also suggest if dysregulation of NMDA receptor subunits promotes ketamine-induced cell death.

TL;DR: Both physical restraint and ketamine sedation altered several physiologic parameters in pregnant and infant rhesus macaques and investigators should consider these effects when designing experiments and evaluating experimental outcomes in monkeys.

TL;DR: The findings indicate that the effects of MPH seem primarily due to decreases in motivation to perform for food, which is not surprising given the well known appetite suppressing effects of amphetamine-like stimulants, and the current data do not strongly suggest cognitive impairments following chronic MPH administration.