Charu Jain

TL;DR: It is shown that high-throughput functional assays targeting fungal adhesion can provide chemical probes for study of multiple aspects of fungal pathogenesis and use chemical genetic experiments to show that it acts downstream of multiple signaling pathways.

TL;DR: A pathogenesis assay using Caenorhabditis elegans, an established model host, with Saccharomyces cerevisiae as the invading fungus is developed, and it is found that yeast infects nematodes, causing disease and death.

TL;DR: The utility of Caenorhabditis elegans is demonstrated by exploring the role of reactive oxygen species (ROS) as a critical innate response against C. albicans infections and validates the ROS-mediated host defense mechanism in mammalian phagocytes by demonstrating that chemical inhibition of the NADPH oxidase in cultured macrophages enables the otherwise susceptible cap1 mutant to resists ROS- mediated phagolysis.

TL;DR: The blood culture positivity along with their antimicrobial susceptibility is the need of the hour in order to aid hospitals to formulate and implement antimicrobial stewardship guidelines.

TL;DR: Fungal BSI has emerged as an important cause of morbidity and mortality in neonates and reporting of fungal bloodstream infections and the spectrum of species involved are essential measures in neonatal intensive care units in order to implement appropriate preventive and therapeutic strategies.